Introduction: Amyloidosis has two principle types: multiple myeloma-associated (AL) and amyloidassociated amyloidosis (AA). Both types can be local or systemic and can often involve the liver. Hepatic amyloidosis carries a poor prognosis, but commonly presents with a more gradual time course of evolving hepatomegaly and elevated serum alkaline phosphatase. This casereport involves an unusual pr...

Introduction: Macrophage activation syndrome (MAS) is a rare but life-threatening systemic inflammatory complication, usually arising from superimposed viral infections or flares of underlying rheumatological conditions. It is characterized by an uncontrolled immune response, involving the expansion of T-Cells, Macrophages, and the hypersecretion of proinflammatory cytokines. The pathophysiolog...

Qadri I, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-221401 Description The drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) is a potentially life-threatening drug-induced reaction characterised by a severe skin eruption, fever, haematological abnormalities (eosinophilia or atypical lymphocytes) and internal organ involvement (liver is the most common). These manifestat...

Here in we report a diagnostically challenging case of adult hemophagocytic lymphohistiocytosis (HLH) triggered by disseminated tuberculosis and Klebsiella pneumoniae co-infection an immunocompetent Individual. She was young female presented with complaints fever, abdominal pain jaundice. Her evaluation showed cytopenias, hyperbilirubinemia, transaminitis, hepatosplenomegaly. progressed to have...

Background and Aim: Autoimmune sclerosing cholangitis is a form with strong autoimmune features overlapping those of hepatitis. It characterized by inflammation the intra- and/or extrahepatic bile ducts, duct dilatation, narrowing obliteration, and, histologically, inflammatory damage leading to periductular fibrosis. Concomitant bowel disease seen in 50% cases. it as prevalent AIH children sim...

Chikungunya is a re-emerging mosquito-borne viral infection that has spread from East Africa to Indian Ocean islands and re-emerged in India since 2004. In Malaysia, chikungunya re-emerged after a hiatus of seven years, causing a localised outbreak in a north-western coastal town in 2006 and subsequently widespread outbreaks in 2008. Since the first local outbreak of chikungunya in Singapore in...

OBJECTIVE To study the pattern of the clinical presentation, laboratory findings and mortality risk among patients infected by scrub typhus in Western Himalayan region of India. METHODS We studied all serologically confirmed cases of scrub typhus admitted to our hospital from July 2010 through December 2011. Presence of IgM antibodies to scrub typhus antigens by ELISA was considered as serolo...