A fascinating aspect of the Diels–Alder reaction is its endo selectivity. This endo preference is much less pronounced in intermolecular cases compared with the intramolecular and transannular Diels–Alder (IMDA and TADA) reactions. Nevertheless, high endo selectivity is observed in the Diels– Alder additions of (E)-1-O-substituted dienes catalyzed by Lewis acids that lead to cis-1,6-disubstitut...

Methods This paper studies a group of 71 patients operated in Heart Institute between September 1st 2001 and July 1st 2006, all surgically corrected without prior palliations. The surgical techniques were: transannular patch (46), infundibular patch ± PA patch (17), and transatrial and transpulmonary correction (8). The patients were divided into 2 groups, operated below 1 year of age and above...

In the title organometallic complex, [Sb(C(20)H(23)N)Cl], the central anti-mony-containing part of the complex exhibits a pseudo-trigonal-bipyramidal geometry, where two C atoms and a lone electron pair of the Sb atom exist at the equatorial positions, while the N and Cl atoms are located at the apical positions, and a transannular inter-action exists between the Sb and N atoms on 1,5-aza-stibo...

A highly stereocontrolled, convergent total synthesis of kendomycin [(-)-TAN2162], an ansa-macrocyclic antibiotic, is reported. The key of the strategy is an unprecedented Tsuji-Trost macrocyclic etherification, followed by a transannular Claisen rearrangement to construct the 18-membered carbocyclic framework. The oxa-six- and five-membered rings were also stereoselectively constructed respect...

[reaction: see text]Transannular macrocyclizations via intramolecular B-alkyl Suzuki reactions are described. Regioselective terminal olefin hydroboration with 9-BBN followed by Pd(0)-catalyzed Suzuki reaction in the presence of a base such as TlOEt at high dilution generates macrocycles with a high degree of control over olefin geometry with isomerically pure E or Z vinyl iodide substrates. Th...

A concise total synthesis of rac-alsmaphorazine D has been described for the first time. The efficient synthetic strategy features four key transformations: 1) a catalytic intramolecular oxidative cyclization for the δ-lactamindole backbone; 2) an oxidative cyclic aminal formation for the hexahydropyrrolo[2,3-b]pyrrole framework; 3) a transannular radical cyclization for the construction of the...

The cyclic acyldepsipeptide (ADEP) antibiotics are a new class of antibacterial agents that kill bacteria via a mechanism that is distinct from all clinically used drugs. These molecules bind and dysregulate the activity of the ClpP peptidase. The potential of these antibiotics as antibacterial drugs has been enhanced by the elimination of pharmacological liabilities through medicinal chemistry...