The action of a novel cardiotonic agent N-hydroxy-5,6-dimethoxy-benzo[b]thiophene-2-carboximide hydrochloride (Org 30029) on intracellular aequorin light transients and isometric contractions was investigated in isolated canine ventricular trabeculae. The positive inotropic effect of Org 30029 (30 ,uM-3 mM) was consistently associated with prolongation of the duration of contraction and an incr...

Peripheral sensory nerve terminals (PSNTs) have a dual function: reporting normal and abnormal sensations and releasing trophic factors to maintain the structure and function of epithelial cells. Although it is widely considered that intracellular Ca2+ plays a critical signaling role for both functions, the role of Ca2+ signaling has never been studied in PSNTs, primarily because of their small...

We present the first experimental observation of superpersistent chaotic transients. In particular, we investigate the effect of noise on phase synchronization in coupled chaotic electronic circuits and obtain the scaling relation that is characteristic of those extremely long chaotic transients.

ABSTRACT Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) is a dedicated mission, launched in December 2020, for gamma-ray transients, including bursts (GRBs) and soft gamma repeater (SGR) the multimessenger multiwavelength astronomy era. Since GECAM consists of two independent spacecrafts (or say instruments), framework data analysis multiple distinctive from ...

BACKGROUND Serum neopterin concentrations rise during activation of the cellular immune system. It is suggested that neopterin interacts with cellular redox mechanisms. This induces oxidative stress, which inhibits intracellular Ca2+ transients in various cell types. In type II alveolar epithelial cells, Ca2+ increase is considered involved in the exocytosis of surfactants. This exocytosis is d...

We have used quartz Ca2+-sensitive microelectrodes (CASMs) in large voltage-clamped snail neurones to investigate the inward spread of Ca2+ after a brief depolarisation. Both steady state and [Ca2+]i transients changed with depth of penetration. When the CASM tip was within 20 microm of the far side of the cell the [Ca2+]i transient time to peak was 4.4+/-0.5s, rising to 14.7+/-0.7s at a distan...

The action of a novel cardiotonic agent N-hydroxy-5,6-dimethoxy-benzo[b]thiophene-2-carboximide hydrochloride (Org 30029) on intracellular aequorin light transients and isometric contractions was investigated in isolated canine ventricular trabeculae. The positive inotropic effect of Org 30029 (30 microM-3 mM) was consistently associated with prolongation of the duration of contraction and an i...

We apply time-frequency analysis to various acoustic transients. Estimates of the conditional mean frequency and the conditional bandwidth exhibit characteristic trends for different transients. This information may be helpful in distinguishing between different classes of transients, and in understanding the underlying mechanisms generating the transient. 1. INTRODUCTION One of the primary mea...

Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 The Hadley Cell . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Rossby Wave Radiation . . . . . . . . . . . . . . . . . . . . . . . . 9 Eddy Flux Closure. . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Stationary Eddies and Their Interaction with Transients . . . . . . . . . . . 20 5.1. Extratropical Statio...

We present the Automated Photometry Of Transients (AutoPhOT) package, a novel automated pipeline that is designed for rapid, publication-quality photometry of astronomical transients. AutoPhOT built from ground up using Python 3 - with no dependencies on legacy software. Capabilities include aperture and point-spread-function photometry, template subtraction, calculation limiting magnitudes thr...