Targeting of most integral membrane proteins to the endoplasmic reticulum is controlled by the signal recognition particle, which recognizes a hydrophobic signal sequence near the protein N terminus. Proper folding of these proteins is monitored by the unfolded protein response and involves protein degradation pathways to ensure quality control. Here, we identify a new pathway for quality contr...

Translation-dependent quality control pathways such as no-go decay (NGD), non-stop (NSD), and nonsense-mediated (NMD) govern protein synthesis proteostasis by resolving non-translating ribosomes preventing the production of potentially toxic peptides derived from faulty aberrant mRNAs. However, how translation is altered in vivo defects that arise absence these are poorly understood. Here, we s...

Introduction: The evaluation of X-ray and light field coincidence in linear accelerators as a quality control test is often performed subjectively, involving the manual marking of films and their visual inspection following the irradiation. Therefore, the present study aimed to develop an objective method for the performance of this test leading to the increased levels...

background: quality assurance in the hematology laboratory is a must to ensure laboratory users of reliable test results with high degree of precision and accuracy. even after so many advances in hematology laboratory practice, pre-analytical errors remain a challenge for practicing pathologists. this study was undertaken with an objective to evaluate the types and frequency of preanalytical er...

Naively collecting translations by crowdsourcing the task to non-professional translators yields disfluent, low-quality results if no quality control is exercised. We demonstrate a variety of mechanisms that increase the translation quality to near professional levels. Specifically, we solicit redundant translations and edits to them, and automatically select the best output among them. We prop...

Naively collecting translations by crowdsourcing the task to non-professional translators yields disfluent, low-quality results if no quality control is exercised. We demonstrate a variety of mechanisms that increase the translation quality to near professional levels. Specifically, we solicit redundant translations and edits to them, and automatically select the best output among them. We prop...