Post-translational modifications act as rheostats of protein activity. Many them reflect environmental variations and allow the cell to give an adapted response these changes. In this cover article #Ref, Céline Schulz collaborators provide in-depth overview still underrated role nutrient-dependent post-translational modification O-GlcNAcylation in regulation metabolism lipids, a very heterogeno...

Recently a first genome-wide analysis of translational regulation using prokaryotic species had been performed which revealed that regulation of translational efficiency plays an important role in haloarchaea. In fact, the fractions of genes under differential growth phase-dependent translational control in the two species Halobacterium salinarum and Haloferax volcanii were as high as in eukary...

Treatment of dominantly inherited muscle disorders remains a difficult task considering the need to eliminate the pathogenic gene product in a body-wide fashion. We show here that it is possible to reverse dominant muscle disease in a mouse model of facioscapulohumeral muscular dystrophy (FSHD). FSHD is a common form of muscular dystrophy associated with a complex cascade of epigenetic events f...

Microarray technology is rapidly becoming a standard laboratory technique. The main challenges related to the successful implementation of the technology are analysis-related. In this article we provide a practically oriented review focusing on methods for analysis of large-scale gene expression data in the research laboratory. We describe the various common clustering methods and outline our a...

Translational epidemiology is the study of risk factors and diseases in large populations, harnessing the power of modern phenotyping, including large-scale omics approaches. In this review, we comment on the power and limitations of modern molecular translational epidemiology and suggest collaborative team science as a specific avenue to secure its existence in the next era of genomic research.

Translational epidemiology is the study of risk factors and diseases in large populations, harnessing the power of modern phenotyping, including large-scale omics approaches. In this review, we comment on the power and limitations of modern molecular translational epidemiology and suggest collaborative team science as a specific avenue to secure its existence in the next era of genomic research.

The ultimate aim of biomedical research is to preserve health and improve patient outcomes. However, by a variety of measures, preservation of kidney health and patient outcomes in kidney disease are suboptimal. Severe acute kidney injury has been treated solely by renal replacement therapy for over 50 years and mortality still hovers at around 50%. Worldwide deaths from chronic kidney disease ...