Coronary Artery Disease (CAD) patients to decrease the incidence of cardiovascular events.1 Above all, mucosal injuries associated with inhibition of prostaglandin synthesis, resulting in GI ulceration and bleeding, is a major side effect of the drug.1 Therefore, a concomitant use of Aspirin and Proton Pump Inhibitors (PPIs) has been approved for CAD patients to prevent mucosa associated disord...

Gastric mucosal disease is frequently recognised in equine practice, especially, but not exclusively, in actively performing race and competition horses. Although true ulceration is commonly seen in squamous mucosal disease (Figure 1), its subjacent glandular mucosal neighbour is affected more frequently by inflammatory and erosive lesions (Figure 2). Research efforts have helped provide us wit...

Effect of methanolic extract of P. Pinnata roots (PPRM) was studied against various experimental gastric ulcer models and offensive and defensive gastric mucosal factors in rats. An initial dose-response study using 12.5-50 mg/kg P. Pinnata root extract, when given orally in two divided dose for 4 days + 5th full dose on the day of experiment 60 min before the experiment, indicated 25 mg/kg as ...

The complication of intestinal haemorrhage in a patientwithmeningococcal septicaemia is described. The patientpresentedwithhaemodynamic instability associated with melaena within an intensive care unit. Upper and lower gastrointestinal endoscopy and angiography failed to localise the source of bleeding. At laparotomy, an isolated small bowel lesion was easily identified and resected. Histologic...

Gangliocytic paragangliomas (GPs) are rare tumors of the duodenum, presenting as single sessile or pedunculated polypoid masses. Clinical manifestations of duodenal GPs can vary from an incidental finding at endoscopy to frequent upper gastrointestinal bleeding caused by mucosal ulceration and abdominal pain. GPs are considered benign, but the disease can recur and spread to regional lymph node...

Lichen planus is a chronic inflammatory mucocutaneous disease. Mucosal lesions are classified into six clinical forms and there is malignant potential for two forms of OLP; therefore, follow-up should be considered. There are many un-established etiological factors for OLP and some different treatment modalities are based on etiology. The aims of current OLP therapy are to eliminate mucosal ery...

The classic Dieulafoy lesion is a minute gastric mucosal defect which bleeds massively from an exposed artery. The typical endoscopic appearance of this lesion is a single, round mucosal defect with an artery protruding from its base in the absence of surrounding ulceration. We encountered an 89-year-old man who developed sudden massive fresh rectal bleeding. The source of hemorrhage was found ...

INTRODUCTION Traditional frontal sinus stents serve only as mechanical devices. It has been proposed that stents also may serve as drug-delivery systems for the topical application of drugs that minimize postoperative scarring. Paclitaxel (Taxol), which has recognized antiscarring effects, may be incorporated via a polymeric formulation into standard rubber stents. The impact of topically appli...

Emerging evidence supports a pathological link between vitamin D deficiency and the risk of inflammatory bowel disease (IBD). To explore the mechanism we used the dextran sulfate sodium (DSS)-induced colitis model to investigate the role of the vitamin D receptor (VDR) in mucosal barrier homeostasis. While VDR(+/+) mice were mostly resistant to 2.5% DSS, VDR(-/-) mice developed severe diarrhea,...

SOMETIMES the antrum of the stomach is almost occluded by a thin mucosal membrane or diaphragm stretched across the lumen. A central aperture, often very small, allows slow imperfect emptying of the upper loculus (which comprises most of the stomach) into the distal antrum, and into the duodenum. If nutrition is maintained at all, the level at which it is maintained depends on the size of the c...