Hodgkin lymphoma (HL) has become one of the best curable malignancies today. This is particularly true for patients with early-stage disease. Today, most patients in this risk group are treated with a combination of chemotherapy followed by small-field radiotherapy. More recent clinical trials such as the German Hodgkin Study Group (GHSG) HD10 study demonstrated, that even two cycles of ABVD fo...

STUDY OBJECTIVE: To evaluate the efficacy of hysteroscopic adhesiolysis and subsequent fertility in patients with adhesions stage 3 and 4. DESIGN: A retrospective cohort study (Canadian Task Force classification II-2). SETTING: A tertiary referral center for hysteroscopic surgery. PATIENTS: Seventy-one patients with intrauterine permanent adhesions. INTERVENTIONS: Hysteroscopic surgery with mon...

Surgical treatment of cervical cancer has been a cornerstone in the management of this malignancy for more than 100 years. Today, for early-stage and low-risk cervical cancer, surgery is still considered the gold standard. If the preoperative assessment of the tumor reveals a situation prompting postoperative adjuvant radiochemotherapy, the latter should be planned as the primary treatment opti...

statement of problem: some vertical changes might be observed during the first stage of orthodontic treatment, aligning and leveling. purpose: the aim of this study was to evaluate dental and/or skeletal vertical changes occurring in the first stage of preadjusted orthodontic treatment. materials and methods: fourteen patients with an average age of 14.1 years were selected for this study. prea...

Hodgkin lymphoma (HL) is an uncommon lymphoid malignancy which accounts for about 0.5% to 1% of all cancers. In 2010, an estimated 8,490 new cases and 1,320 deaths will occur in the United States (Jemal, Siegel, Xu, et al, 2010). HL incidence appears to be stable over the past few decades, in contrast to the incompletely understood continued increase in frequency of non-Hodgkin lymphomas. HL ha...

The treatment of early-stage gastric lymphoma is controversial. This retrospective analysis reports on the outcome of 24 patients treated in our institution during the past 25 years. Fourteen patients had stage IEA, one patient had IEB, six patients IIEA1, and three patients had stage IIEA2 non-Hodgkin's lymphoma (NHL). Diffuse large cell intermediate-grade NHL was diagnosed in 17 patients, dif...

Advanced-stage Hodgkin lymphoma (HL) usually includes all patients diagnosed in Ann Arbor stages III and IV. Many groups also include patients with stage IIB and additional risk factors such as large mediastinal mass and/or extranodal disease. Historically, less than 5% of these patients survived when left untreated or received singleagent chemotherapy. With the development of multi-agent chemo...

The molecular classification of melanoma and the advent of new drugs are changing the paradigm of therapy for advanced melanoma. A review of the recent key studies was performed, followed by a discussion in an expert forum. The aim of this review was to generate a therapeutic algorithm for stage IV melanoma. Tumor genotyping for BRAF and/or KIT should be performed before selection of therapy. F...

BACKGROUND Disease-free survival after surgical resection of lung carcinoma in situ has been reported as over 90%. After resection of stage IA non-small cell lung cancer, survival at 5 years is approximately 60% to 70%. If endoscopic or bronchoscopic treatments of early-stage lung cancer can provide similar disease-free survival with less perioperative mortality, morbidity, and cost, then they ...