Background: Cancer is one of the biggest health problems worldwide, with lung cancer as first rank in number new cases and deaths. Non-small cell carcinoma (NSCLC) a type that accounts for about 85% all cases. Previous research identified role epidermal growth factor receptor (EGFR) most suitable target to treat NSCLC. This study aims identify potential compounds derived from mangrove plants ag...

many properties of chemicals depend on their stereochemistry. among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. we have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. as, depending on their lipophilicity, penetration enhancers can change ...

Topica] tretinoin (Retin-A• , Ortho Pharmaceuticals) was applied for 6-9 months to photoaged faces of 27 Chinese, mostly women, living in North China where climatic conditions are very unfavorable. Summers are hot and sunny, predisposing to photodamage. The weather is also frequently dry and windy predisposing to dryness. The results were similar to those previously described on Orientals in Th...

BACKGROUND Even facial pigmentation is considered a universal sign of youth and beauty in all cultures and at all ages in both men and women. The recent FDA concern about the safety of topical hydroquinone has provided the impetus for research into new pigment lightening alternatives in the cosmetic OTC market. AIM This research examined a novel hydroxyphenoxy propionic acid, ellagic acid, ye...

IL-2: interleukin-2 INTRODUCTION The treatment of in-transit and satellite melanoma metastases is challenging. Treatment options for these cutaneous and subcutaneous lesions include surgical excision, radiotherapy, isolated limb infusion/perfusion, electrochemotherapy, cryotherapy, laser therapy (pulsed dye or carbon dioxide), systemic treatment with interferon-a or interleukin-2 (IL-2), topica...

INTRODUCTION Hydroquinone is the best studied andmost widely used topical depigmenting agent, and represents the gold standard for treatment of disorders of pigmentation. Although ochronosis is a known sequela of long-term hydroquinone use, pigmentation of the nails is rarely a reported side effect. We present a case of identical twins who developed hyperpigmentation of identical nails after th...

Evidence from a randomized clinical trial showed that, in spite of the many surgical procedures effective in ameliorating the clinical appearance of photoaged skin, the only medical therapy with proven benefits in photoaged skin are topical retinoids, in particular tretinoin, isotretinoin, and tazarotene. The application of retinoids might not only clinically and biochemically repair photoaged ...

Recent studies suggest that retinoids may be effective in the treatment of Alzheimer's disease, although exposure to an excess of retinoids during gestation causes teratogenesis. Cholesterol is essential for brain development, but high levels of cholesterol have been associated with Alzheimer's disease. We hypothesized that retinoic acid may affect cholesterol homeostasis in rat astrocytes, whi...

PURPOSE The aim of the present research was to formulate a transparent microemolsion as a topical delivery system for tretinoin for the treatment of acne. METHODS Microemulsion formulations prepared by mixing appropriate amount of surfactant including Tween 80 and Labrasol, co-surfactant such as propylene glycol (PG) and oil phase including isopropyl myristate - transcutol P (10:1 ratio). The...