The design of compounds suitable for drug development is a multi-dimensional process that requires the ne tuning of molecular properties beyond potency. For instance, physical– chemical properties that directly affect hydrolytic stability and bioavailability of the compound must be addressed to avoid side effects in vivo. Due to the excellent pharmacological prole of uorinated drugs, the str...

We present and implement a fourth-order projective dependency parsing algorithm that effectively utilizes both “grand-sibling” style and “tri-sibling” style interactions of third-order and “grand-tri-sibling” style interactions of forth-order factored parts for performance enhancement. This algorithm requires O(n5) time and O(n4) space. We implement and evaluate the parser on two languages—Engl...

The conformation of d(TA)3 (CG)3 has been studied in aqueous solution in the presence of high salt concentration. The oligonucleotide forms in solution concatamers. In the presence of 5 M NaC1 the concatamer is built up of d(CG)3 blocks in Z-conformation and of d(TA)3 blocks in B-conformation. In the presence of 4 M LiCl both blocks in the concatamer display a B-type structure.

[Purpose] The purpose of the present study was to investigate the effectiveness on the educational procedure development for physical therapist assistant in Quang Tri province of Vietnam. [Subjects and Methods] The subjects consisted of 10 lecturers for the education of physical therapist assistant in Quang Tri medical college. To compare with satisfaction and educational effectiveness accordin...

The synthesis of InP nanofibers via a new Ullmann-type reaction of indium nanoparticles with tri(m-tolyl)phosphine (P(PhMe)(3)) was typically performed to illustrate an alternative route for the preparation of nanostructured metal phosphides, including III-V (13-15) and transition-metal phosphides. Triarlyphosphine compounds such as other two tri(m-tolyl)phosphine isomers, diphenyl(p-tolyl)phos...

Let A be a C*-algebra. Let z be the maximal atomic projection and p a closed projection in A∗∗. It is known that x in A∗∗ has a continuous atomic part, i.e. zx = za for some a in A, whenever x is uniformly continuous on the set of pure states of A. Under some additional conditions, we shall show that if x is uniformly continuous on the set of pure states of A supported by p, or its weak* closur...

The aim of this paper is to show that if an order preserving bijective transformation of the Hilbert space effect algebra also preserves the probability with respect to a fixed pair of mixed states, then it is an ortho-order automorphism. A similar result for the orthomodular lattice of all sharp effects (i.e., projections) is also presented.

A mass‐balance model for Lake Superior was applied to polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and mercury to determine the major routes of entry and the major mechanisms of loss from this ecosystem as well as the time required for each contaminant class to approach steady state. A two‐box model (water column, surface sediments) incorporating seasonally adjuste...

We develop protocols for preparing the GHZ state (a pure tri-partite maximally entangled state) and, in general, a pure n-partite maximally entangled state using EPR pairs shared amongst n agents and classical communication between the agents. We observe that the combinatorial arrangement of EPR pairs required for this purpose is like that in Helly-type theorems in geometry. PACS numbers: 03.65...

the aim of the present study was to investigate whether and by which mechanism; histamine can induce state-dependent retrieval of passive avoidance task. the pre-training or pre-test intracerebroventricular (i.c.v.) injection of histamine (20µg/mouse) impaired retrieval, when it was tested 24 h later. in the animals, which retrieval was impaired due to histamine pre-training administration, pre...