In the title compound, C13H11N3S2, the triazole and thio-phene rings are coplanar [dihedral angle = 6.22 (13)°]. By contrast, the phenyl ring is perpendicular to the triazole ring [dihedral angle = 85.58 (13)°], so that the mol-ecule has an L-shape. The thio-phene S atom is syn with the ring imine N atom. In the crystal, eight-membered {⋯HNCS}2 synthons form between centrosymmetrically related ...

The Objective of this study is created a novel derivative the naproxen with heterocyclic (1,2 and 4 triazole) ring that reacted benzoyl chloride derivatives, as well preliminary antibacterial activity testing formed products. derivatives are synthesized by esterifying hydrazine hydrate, then reacting hydrated carbon disulfide, finally reaction (in final step) triazole including amino group via ...

The synthesis and characterisation of axially chiral atropisomeric 1,5-disubstituted 1,2,3-triazoles is reported. Molecules designed to display restricted rotation about 1,2,3-triazole N-1-aryl or C-5-aryl bonds were investigated by physical computational techniques. barrier was found be higher than that for rotation, confirming axial chirality stemming from an bond in a the most suitable devel...

In the title compound, C28H23N3O, the 1,2,4-triazole ring deviates slightly from planarity adopting a (N3)TC2 conformation which is distorted towards an EC2 conformation. The plane around the ethyl-ene unit makes a dihedral angle of 17.32 (11)° with the mean plane [r.m.s. deviation = 0.036 (1) Å] of the 1,2,4-triazole fragment. The dihedral angles between the four phenyl rings and the 1,2,4-tri...

The title compound, C10H10N4OS, is nearly planar with the mean planes of the hy-droxy-benzyl and triazole rings inclined at an angle of only 3.2 (7)°. In the crystal, O-H⋯N hydrogen bonds between the hy-droxy group and the triazole ring in concert with weak N-H⋯S inter-molecular inter-actions between the triazole ring and thione group form chains along [-210] enclosing R 2 (2)(8) graph-set moti...

New 1,4- and 2,4-substituted 1,2,3-triazole derivatives were synthesized and tested as potential BK(Ca) channel openers, as a part of a research program, which hypothesizes a pharmacophoric structure containing the 1,2,3-triazole ring. The structure-activity relationships were studied introducing some structural changes concerning molecular geometry and the presence of a hydrogen bond donor as ...

The synthesis of a series halogen bonding (XB) acyclic anion receptors based on novel 1,2-iodo-triazolium-triazole benzene motif is reported. A combination one- and two-dimensional 1H 19F NMR spectroscopic techniques elucidate key conformational effects associated with the incorporation ortho-substituted iodo-triazole XB donors. titration experiments highlight recognition potency mono-cationic ...

The leading fungal pathogens causing systemic infections in humans are Candida spp., Aspergillus fumigatus , and Cryptococcus neoformans . major class of antifungals used to treat such the triazoles, which target cytochrome P450 lanosterol 14-α-demethylase, encoded by ERG11 (yeasts)/ cyp51A (molds) genes, catalyzing a key step ergosterol biosynthetic pathway. Triazole resistance clinical fungi ...

The title compound, C(20)H(12)Cl(3)N(3)O(2), was synthesized by the reaction of 2-(2-hydroxy-phen-yl)benz[e][1,3]oxazin-4-one with 2,4,6-trichloro-phenyl-hydrazine in ethanol. The trichloro-phenyl ring is nearly perpendicular to the triazole plane [dihedral angle 80.56 (8)°], whereas the two hydroxy-phenyl rings are approximately coplanar with the triazole ring [dihedral angles of 2.79 (12) and...

The title compound, C(9)H(10)N(4)S·0.095H(2)O, consists of discrete 4-ethyl-3-(3-pyrid-yl)-1H-1,2,4-triazole-5(4H)-thione mol-ecules and a disordered mol-ecule of water of hydration with partial occupancy, lying on a twofold rotation axis. The dihedral angle between the pyridine and triazole rings is 41.73 (8)°. In the crystal structure, mol-ecules are hydrogen bonded via triazole NH groups and...