Thiazolotriazole derivatives have a number of biological activities. Electrophilic intramolecular cyclization unsaturated alkyl 1,2,4-triazole under the action various electrophilic reagents (halogens, tetrahalides chalcogenides) is most effective and simple method synthesis thiazolotriazoles.
 It was previously reported that 3-metalylthio-4,5-diphenyl-1,2,4-triazole reacts with aryltellur...

The study investigated the corrosion-inhibitory properties of three synthetic triazole Mannich bases on C1018 carbon steel using various electrochemical techniques. inhibitors, namely 4-amino-2-[(4-methylpiperazin-1-yl)methyl]-5-(pyridin-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (4MPT), 4-amino-2-[(piperidin-1-yl)methyl]-5-(pyridin-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (PPT) and 4-ami...

A reaction of equimolar equivalents 1-(4-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide (1) and indoline-2,3-dione (2) in boiling ethanol for 4 h under acidic conditions gave 1-(4-methoxyphenyl)-5-methyl-N’-(2-oxoindolin-3-ylidene)-1H-1,2,3-triazole-4-carbohydrazide (3) 88% yield. The structure 3 was ascertained by NMR spectroscopy single-crystal X-ray diffraction.

a series of 2-(4-nitro-1-imidazolylmethyl)-1,3,4-oxadiazole, 1,3,4-triazole and 3-(4-nitro-1-imidazolylmethyl)-1,2,4-triazole derivatives were synthesized and tested for their antimicrobial activity. some of the tested compounds were active against staphylococcus aureus, staphylococcus epidermidis, bacillus subtilis, clostridium difficile, aspergillus niger and cryptococcus neoformans.

Purpose: To synthesize new triazole derivatives in order to overcome the problem of side effects antimicrobial agents and microbial resistance, while broadening spectrum activity.
 Methods: The starting triazole, compound 1, was prepared through click chemistry reacted with chloroacetyl chloride yield II. Triazole 1 acids aldehydes produce oxadiazole (III) azomethine (IV) which cyclized ac...

Planar mol-ecules of the title compound, C(3)H(4)N(4)O, are organized into sheets by extensive N-H⋯O and N-H⋯N hydrogen bonding in the (101) plane of the crystal structure. These hydrogen bonds may also stabilize the mol-ecule in the Z form. The title compound is in the amide form, as shown by the C=O bond length [1.252 (2) Å].

The asymmetric unit of the title compound, C(2)H(2)N(4)O(2), contains two crystallographically independent mol-ecules in which the triazole rings are essentially planar, with maximum deviations of 0.003 (1) Å in both molecules. The dihedral angle between the two 1H-1,2,4-triazole rings is 56.58 (5)°. In the crystal, mol-ecules are linked via inter-molecular N-H⋯N and C-H⋯O hydrogen bonds, formi...