Biphasic calcium phosphate ceramics (BCP) comprising a mix of non-resorbable hydroxyapatite (HA) and resorbable beta-tricalcium phosphate (beta-TCP) are particularly suitable materials for synthetic bone substitute applications. In this study, HA synthesised by solid state reaction was mechanically mixed with beta-TCP, then sintered to form a suite of BCP materials with a wide range of HA/beta-...

Background: Bone tissue engineering requires materials that are biocompatible, mechanically suited for bone function, integrated with the host skeleton, and support osteoinduction of the implanted cells for new bone formation. The aim of this study was to compare the osteogenic potential of xenograft with hydroxyapatite/β- tricalcium phosphate (HA/β-TCP) scaffold. Methods: New Zealand rabbits (...

An ideal implant needs to have the ability coordinate foreign body response and tissue regeneration. Here, Hydrogenated-silicon nanosheets (H-Si NSs) with favorable biodegradability are integrated functionalized into a β-tricalcium phosphate scaffold TCP) for bone defect healing. H-Si TCP can greatly improve regeneration through osteoimmunomodulation-guided biodegradation in vivo. The spatiotem...

Hydrothermal (H) processes accelerate the hydrolysis reaction of ?-tricalcium phosphate (?-TCP) compared to long-established biomimetic (B) treatments. They are special interest for patient-specific 3D-printed bone graft substitutes, where manufacturing time represents a critical constraint. Altering conditions has implications physicochemical properties product. However, impact changes produce...

OBJECTIVE In the present study, we aimed to assess whether gelatin/β-tricalcium phosphate (β-TCP) composite porous scaffolds could be used as a local controlled release system for vancomycin. We also investigated the efficiency of the scaffolds in eliminating infections and repairing osteomyelitis defects in rabbits. METHODS The gelatin scaffolds containing differing amounts of of β-TCP (0%, ...

Human platelet-derived growth factor-BB (hPDGF-BB) is a basic polypeptide growth factor released from platelets at the injury site. It is a multifunctional molecule that regulates DNA synthesis and cell division and induces biological effects that are implicated in tissue repair, atherosclerosis, inflammatory responses, and neoplastic diseases. This paper is an overview of the toxicology data g...

Many properties of porous calcium phosphate ceramics have been described, but how pore size influences bony integration of various porous ceramics remains unclear. This study was performed to quantify the bony ingrowth and biodegradability of two porous calcium phosphate ceramics with four different pore size ranges (45-80 microm, 80-140 microm, 140-200 microm, and 200-250 microm). Hydroxyapati...

The aim of this study was to investigate the effect of the pore characteristics of β-tricalcium phosphate (β-TCP) on periodontal healing in class III furcation defects in dogs. Two types of β-TCP were prepared for grafting; 1) a tunnel pipe structure with an inner diameter of 300 μm, and 2) continuous pore structure with interconnected macropores. The furcations of thirty mandibular premolar te...