Background: Trimethyltin (TMT) is a toxic agent that causes oxidative stress, laboratory model for inducing hippocampal injuries. Pentoxifylline (PTX) inhibits phosphodiesterase, inflammation and stress. This study evaluated the neuroprotective effects of PTX on injuries induced by TMT in hippocampus. Methods: Sixty male Wistar rats were divided into five groups 12 each. Group 1 received normal...

conclusions the results of this study supported the potential protective effects of zncl2 on rat kidney tissues against cdcl2 toxicity. results in contrast to the animals that received zncl2, cdcl2 induced a dose-dependent elevation in bun, creatinine, and mda in those without zncl2 pretreatment. zinc chloride had significantly decreased all biochemical parameters and protected kidney cells aga...

Introduction: Trimethyltin Chloride (TMT) is a neurotoxin that can kill neurons in the nervous system and activate astrocytes. This neurotoxin mainly damages the hippocampal neurons. After TMT injection, behavioral changes such as aggression and hyperactivity have been reported in animals along with impaired spatial and learning memory. Hence, TMT is a suitable tool for an experimental model of...

Nuclear factor (NF)-kappaB p50 protein is involved in promoting survival in hippocampal neurons after trimethyltin (TMT)-injury. In the current study, hippocampal NF-kappaB activity was examined and quantitated from transgenic kappaB-lacZ reporter mice after chemical-induced injury. NF-kappaB activity was localized primarily to hippocampal neurons and significantly elevated over that in saline-...

Dear Editor, Trimethyltin (TMT) is a by-product of organotin compounds, which are widely used as heat stabilizers. Unfortunately, TMT is a toxicant affecting several organs, including the brain.1 Herein we describe a case of TMT intoxication characterized by symmetrical leukoencephalopathy and severe hypokalemia. A previously healthy 22-year-old man presented with subacute headache, amnesia, an...

The environmental contaminant, trimethyltin (TMT), produces a profound elevation in tone intensity necessary to inhibit the acoustic startle reflex in laboratory animals which recovers over a prolonged period except at very high frequencies. The recovery that is observed does not begin until 3 to 5 weeks after a single acute administration depending upon dosage. As opposed to the very temporary...

Trimethyltin (TMT) is a potent neurotoxicant that affects various regions within the central nervous system, including the neocortex, cerebellum, and hippocampus. In the present study, ginsenoside Rd was investigated as a candidate neuroprotective agent in a primary hippocampal neuron culture and mouse models. TMT induced neurotoxicity in a seven-day primary hippocampal neuron culture in a dose...