Aim Absorption of ammonia from the gut has consequences that range encephalitis in hepatic disease to global climate change induced by nitrogenous excretions livestock. Since patch clamp data show certain members transient receptor potential (TRP) family are permeable NH4+, participation ammonium efflux was investigated. Methods Digesta, mucosa and muscular samples stomach, duodenum, jejunum, i...

Chronic pruritus (itch) is a widespread and debilitating condition associated with dermatologic, systemic, neuropathic, or psychogenic disorders. The pathophysiologic mechanisms underpinning the transduction potentiation of this refractory remain unclear. Current therapeutics are largely ineffective.1Weidinger S. Beck L.A. Bieber T. Kabashima K. Irvine A.D. Atopic dermatitis.Nat Rev Dis Primers...