it has been reported that several members of convolvulaceae family such as convolvulus arvensis possess cytotoxic activity on some tumor cell lines. proteoglycan mixture, the water extract of c. arvensis with high molecular weight, has potent anti-angiogenesis and stimulating effects. in this study, arial parts of c. arvensis were collected and identified, and the cytotoxic effects of chlorofor...

Background: Ligustrazine, active ingredients extracted from the natural herb Ligusticum Chuanxiong Hort, has promising anti-tumor properties on tumor cell lines. However, potential activity of ligustrazine colorectal cancer (CRC) cells and molecular mechanisms have not been elucidated. In this study, we explored critical functions SW480 CT26 at cellular levels.

Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target for the development of α-MSH peptide based imaging and therapeutic agents. In this work a new lactam bridge α-MSH analogue was synthesized and radiolabeled with 99mTc via HYNIC chelator and tricine as co-ligand. Also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...

melanocortin-1 (mc1) receptor is an attractive melanoma-specific target for the development of α-msh peptide based imaging and therapeutic agents. in this work a new lactam bridge α-msh analogue was synthesized and radiolabeled with 99mtc via hynic chelator and tricine as co-ligand. also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...

brown tumors may occur secondary to hyperparathyroidism in patients with chronic renal failure (ckd). they are increasingly rare because hyperparathyroidism in now diagnosed and treated at an early stage. we report 67-year-old man who had been on hemodialysis for crf for over 3 years, who presented with back pain over the thoracolumbar junction from 2 years ago and because of pain he could not ...

background: although there is convincing data in support of the effectiveness of hyperthermia in tumor therapy, the molecular mechanisms underlying the clinical effects of hyperthermia are still poorly understood. objective: to investigate natural killer (nk) cell cytotoxicity against heat-treated sw-872 and hela tumor cell lines. methods: nkg2d ligands and hla class i transcription were examin...

recent studies have indicated the profound  anti-tumor activity of artemisinin's compounds,  among  which;  arteether  is an  oil-soluble derivative of  artemisinin with an endoperoxide bridge that can induce apoptosis in tumor cells but not in the normal cells. an experiment was carried out on tumor-bearing balb/c mice to estimate the effects of arteether  on  tumor  growth  and  antitumor  im...

background: invasive ductal carcinoma is the most common type of breast cancer in iran. impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood. it is believed that infiltrated immune cells, especially macrophages, may provide help for tumor cell growth and metastasis.   objective: to analyze the status of tumor as...

Introduction: Ophthalmic plaque radiotherapy using I-125 radioactive seeds in removable episcleral plaques is often used in management of ophthalmic tumors. Radioactive seeds are fixed in a gold bowl-shaped plaque and the plaque is sutured to the scleral surface corresponding to the base of the intraocular tumor. This treatment allows for a localized radiation dose delivery to the tumor with a ...

introduction: a keratocystic odontogenic tumor is a benign intra-bone mass originating from dental lamina or its residue. it represents 2–11% of jaw cysts, and has a slow but aggressive growth. the evaluation of molecular characteristics, immunohistochemistry, and genetic expression currently have no established classification regarding the evolution and pathophysiologic pattern of these lesion...