NF-κB proteins play a complex role in modulating carcinogenesis following DNA damage. Previous work identified p50/NF-κB1 as a necessary factor in the cytotoxic response to alkylation damage. Recently, these findings were extended to demonstrate that in the setting of alkylation damage, this NF-κB subunit acts as a haploinsufficient tumor suppressor that prevents hematologic malignancy formation.

Hepatic tumors readily appear in rats fed a basal ration of carrots and polished rice to which butteryellow (N,N-dimethyl-p-aminoazobenzene) has been added in oil ( i2 , I6), and tumor incidence can be markedly reduced when liver or yeast is added to such a ration at a IO to 15 per cent level (16, 17) or when the basal ration is wheat (I3, 2o). Nutri t ionally the rice-carrot diet is grossly de...

The mechanism of formation of a transplantable ascites tumor was studied to ob serve the origin of tumor cells free in the peritoneal cavity. The development of the ascites tumor was observed to proceed by an initial penetration of tumor cells into the mesentery and retroperitoneal organs within the first day, their proliferation within these structures, and subsequent exfoliation into the flui...