BACKGROUND Tumor-induced osteomalacia is a rare paraneoplastic syndrome characterized by hypophosphatemia, renal phosphate wasting, suppressed 1,25-dihydroxyvitamin D production, and osteomalacia. It is caused by a usually benign mesenchymal tumor producing fibroblast growth factor 23 (FGF-23). Surgical excision of the tumor is the first choice of treatment because complete resection is curativ...

BACKGROUND Tumor-induced osteomalacia (TIO) is a rare syndrome typically caused by mesenchymal tumors. It has been shown that complete tumor resection may be curative. However, to our knowledge, there has been no report of a large cohort to exam different surgical approaches. This study was aimed to assess outcomes of different surgical options of patients with tumor-induced osteomalacia at a s...

Introduction Vitamin D deficiency is the major cause of rickets and osteomalacia, bone diseases which lead to several deformities of the skeleton. This paper gives a review about skeletal evidence of both diseases in Europe. First, it is necessary to explain the main principles of vitamin D metabolism in order to understand causes and effects of vitamin D deficiency. These aspects are followed ...