crohn’s disease is an inflammatory bowel disease (ibd), characterized by chronic intestinal inflammation that causes the loss of immune tolerance leading to bizarre inflammatory signals and disruption of mucosal barriers. environmental triggers and interaction of genetic determinants also play an indispensible role. in this case report, we present a pre-pubertal girl with intermittent and refra...

pre-eclampsia is a pregnancy-specific syndrome that may be dangerous especially to the fetus. different cytokines have been found to be elevated in women with pre-eclampsia and may have possible roles in the development of this disorder. alleles of the interleukin-l-beta (il-lβ) and tumor necrosis factor alpha (tnf-α) genes are associated with pr-eeclampsia in several studies in different popul...

conclusions according to our result, 1525g/a and 1595c/t were in strong linkage disequilibrium and the polymorphisms of the trail gene in the 3’ utr region were not associated with the outcome of hbv infection. results our data showed that genotypes 1525g/a and 1595c/t were in complete linkage disequilibrium and the genotype frequencies at the two positions were the same. no significant differe...

OX40 is a costimulatory molecule that belongs to the tumor necrosis factor receptor (TNFR) superfamily. agonist-based combinations are emerging as promising candidates for novel cancer immunotherapy. Clinical trials have shown agonist antibodies could lead better results in patients. Using hybridoma platform and three different types of immunization strategies, namely recombinant protein, DNA, ...

Colorectal carcinoma (CRC) is one of the most prevalent forms malignant tumors worldwide, with over 600,000 CRC-related deaths occurring annually. Despite major advances in surgical techniques and equipment, chemotherapy radiation therapy, prognosis for CRC patients remains poor because distant metastasis recurrence. Traditionally, identification at high risk recurrence or has depended on ...