Cancer Immunotherapy In article number 2205044, Baorui Liu, Rutian Li, and co-workers constructed gelatinase-responsive NanoSwitch to control the activation process of CAR-T cells, leading on-site cells at tumor region in a sustainable way. This platform has promising potential prevent main obstacles therapy for solid tumors including cytokine-release syndrome on-target/off-tumor toxicity.

Background and Objective: Wilms’ tumor has been recognized as the most common primary malignancy of kidney at childhood, comprises 5-6% of tumors in this period, and manifests itself with various clinical symptoms. Since there have been no sufficient studies in this field in Iran, therefore, this study w...

background: colorectal tumor is one of the main causes of death in our country. the aim of the present study was to determine the clinicopathological aspects of tumor and the presence of hepatic micrometastasis in patients with colorectal cancer (crc). materials and methods: forty two patients with crc were evaluated in the study surgical treatment was performed and liver biopsy was taken for t...

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Surgical site infections (SSIs) are a common complication that follows all types of operative procedures. These infections are usually caused by the exogenous and endogenous microorganisms that enter the operative wound during the course of surgery. The general and procedure-specific risk factors for the development of SSI have been identified and are discussed in this article. Factors that inf...

krukenberg tumor is an interesting and rare tumor which usually but not always is metastatic. ovaries more than any other genital pelvic organs are the site of metastasis. endometrium, gastrointestinal tract and breast are the most common primary sites. the best method of treatment is surgery. postoperatively, radiotherapy and chemotherapy must be performed. 3 cases of krukenberg tumor diagnose...

A placental site trophoblastic tumor requires care in management and a prompt diagnosis. Placental site trophoblastic tumor is a rare type of gestational trophoblastic disease and displays non-specific presentations similar to those of uterine arteriovenous malformation and those of non-neoplastic gestational trophoblastic diseases such as placental polypoid tumor. Diagnosis from biopsy is extr...

background and purpose: cancer and cerebrovascular accidents (cva) are two most common causes of mortality and morbidity in the elderly. patients with brain tumor can be highly affected by postsurgical stroke. cva may be the first manifestation in these patients . therefore, we aimed to assess the epidemiological factors affecting cva after brain surgery. methods: in this cross-sectional study ...