Microtopography In article 2201585, Sajanlal R. Panikkanvalappil and co-workers demonstrate an efficient tumor targeting strategy to deliver systemically administered nanoparticles (NPs) into solid tumors. This technique involves intratumoral implantation of micromagnets, which facilitate enhanced accumulation the novel multimodal magneto-plasmonic NPs at a micromagnet-implanted compared contro...

In article number 2001212 by Huile Gao, Xianchun Chen, and co-workers, recent progress of self-propelled micro/nanomotors for tumor drug delivery is reviewed. The force facilitates with autonomous movement, therefore exhibit potential enhanced efficiency in each step delivery, which includes circulation the blood, targeting, deep penetration, cellular internalization, release. combination thera...

Combination of RGD cell adhesion peptide with GHK modulator synergistically improves targeting tumor cells. Amphiphilic peptides can be effectively displayed on liposomal surface for screening and drug delivery applications.

Recent preclinical studies have suggested that radiotherapy in combination with antiangiogenic/vasculature targeting agents enhances the therapeutic ratio of ionizing radiation alone. Because radiotherapy is one of the most widely used treatments for cancer, it is important to understand how best to use these two modalities to aid in the design of rational patient protocols. The mechanisms of i...

We used dynamic MRI to evaluate the effects of monoclonal antibodies targeting brain tumor vasculature. Female athymic rats with intracerebral human tumor xenografts were untreated or treated with intetumumab, targeting α(V)-integrins, or bevacizumab, targeting vascular endothelial growth factor (n = 4-6 per group). Prior to treatment and at 1, 3, and 7 days after treatment, we performed standa...

Background In order to achieve drug targeting and controlled release, we have successfully developed a novel drug release system DOX/AuNCs-PM-HA with gold nanocages (AuNCs) as photothermal cores, thermally responsive copolymer P(NIPAM-co-Am) (PM) as the near-infrared (NIR) stimuli gatekeeper and hyaluronic acid as a targeting ligand as well as a capping agent. Methods Cell uptake and cell via...