OBJECTIVE To determine whether topical application of insulin normalizes delayed corneal wound healing in rats with diabetes mellitus (DB). METHODS Diabetes mellitus was induced with streptozocin. A 5-mm corneal abrasion at 9 or 11 weeks was treated topically for 7 days (4 times daily) with 1, 2, or 5 U of insulin or with sterile vehicle (SV). RESULTS Residual corneal epithelial defects of ...

Cell-substrate contacts, called focal adhesions (FAs), are dynamic in rapidly moving cells. We show that supervillin (SV)--a peripheral membrane protein that binds myosin II and F-actin in such cells--negatively regulates stress fibers, FAs, and cell-substrate adhesion. The major FA regulatory sequence within SV (SV342-571) binds to the LIM domains of two proteins in the zyxin family, thyroid r...

The article outlines the development of time variable parameter (TVP) estimation as an approach to modeling nonstationary dynamic systems. It then describes one of the latest methods for estimating time variable parameters in dynamic auto-regressive, exogenous variables (DARX) and dynamic transfer function (DTF) models. In the case of DARX models, the estimation methodology is based on standard...

Anterior gradient 2 (AGR2) is a gene predominantly expressed in mucus-secreting tissues or in endocrine cells. Its expression is drastically increased in tumors including prostate cancer. Here we investigated whether AGR2 transcript levels can be used as a biomarker to detect prostate cancer (PCa). Using a PCR-based approach, we could show that in addition to the wild-type (AGRwt long and short...

Simvastatin (SV) is a lactone prodrug used for the treatment of hypercholesterolemia. Upon incubation of SV with liver microsomal preparations from human donors, four major metabolic products were formed (3'-hydroxy SV, 6'-exomethylene SV, 3',5'-dihydrodiol SV, and the active hydroxy acid, SVA), together with several minor unidentified metabolites. The 3',5'-dihydrodiol SV, a new metabolite, wa...

U radu se daje kratak osvrt na život apostola sv. Filipa i Jakova Mlađega. Sv. Filip najprije je bio učenik Ivana Krstitelja. Po redoslijedu pozivanja peti. Jakov poznat kao Alfejev, brat Gospodinov Pravedni. Mlađi Manji nazivan da bi razlikovao od Zebedejeva, koji po pozivanja, treći apostol. deveti Isusov učenik. Njihov spomendan svetkuje istoga dana jer relikvije Mlađega nalaze uz u crkvi Do...

Sedentary time and screen-viewing (SV) are associated with chronic disease risk in adults. Parent and child sedentary time and SV are associated. Parents influence children's SV through parenting styles and role modelling. Understanding whether parents' attitudes toward child SV are associated with their own SV and sedentary time will aid development of family interventions to reduce sedentary ...

OBJECTIVE To investigate liver lobe volumes and the ratios of liver lobe volumes to spleen volume measured with magnetic resonance imaging (MRI) for quantitatively monitoring and staging liver fibrosis. METHODS Animal study was approved by Institutional Animal Care and Use Committee. Sixteen minipigs were prospectively used to model liver fibrosis, and underwent abdominal gadolinium-enhanced ...