Aim: This study was performed to isolate antifungal substance from actinomycetes species found in soil in order to avoid osmophilic food spoilage. Methods: Purified isolates of different actinomycetes collected from soil in Makkah region, Saudi Arabia were screened for their antifungal bioactivity against the unicellular fungal strain, Saccharomyces cerevisiae. The actinomycete isolate that sho...

A two-phase model of heterogeneous explosives, with a reaction rate that is proportional to the gasphase pressure excess above an ignition threshold, is examined computationally. The numerical approach, a variant of Godunov’s method designed to accommodate nonconservative terms in the hyperbolic model, extends previous work of the authors to two-dimensional configurations. The focus is on the b...

In this study, twenty two new N,N-disubstituted dithiocarbamate derivatives were synthesized. The structures of the compounds were confirmed by IR, 1H-NMR, mass spectroscopy and elemental analysis. Anticholinergic activities of the compounds were evaluated by the tests performed on isolated rat ileum and were compared with atropine sulfate. 1-(Diphenylamino)-1-oxopropan-2-yl 4-methylpiperazine ...

Temporin A (TA) and a cecropin A-temporin A hybrid peptide (CATA) were synthesized and assayed for their hemolytic, anticoagulant, and antifungal properties. CATA retains significant antifungal activity, is less hemolytic than TA, and inhibits blood coagulation. These results recommend further studies of the biological activities of CATA.

BACKGROUND AND PURPOSE Studies have demonstrated the importance of early stroke treatment. If a neuroprotective agent (NA) clinical trial is successful, the greatest benefit might be attained with early prehospital administration. This study determined the potential reduction in time to treatment of stroke patients when NAs were administered in the prehospital setting. METHODS Twenty-three ur...

The high mortality rates associated with candidemia episodes and the emergence of resistance to antifungal agents necessitate the monitoring of the susceptibility of fungal isolates to antifungal treatments. The new, recently approved, species-specific clinical breakpoints (SS-CBPs)(M27-S4) for evaluating susceptibility require careful interpretation and comparison with the former proposals mad...