Home medical care is currently widespread. Chronic patients represent a good target for home-care because : (i) the care protocol is precise, clear (e.g peritoneal dialysis, type 1 diabetes), (ii) patients don’t need hospital stay (except medical emergency), (iii) patients perfectly know their chronic disease. The main problem is that the care protocol is often oral and even in the case of writ...

In this paper, we consider the problem of simultaneously testing many two-sided hypotheses when rejections of null hypotheses are accompanied by claims of the direction of the alternative. The fundamental goal is to construct methods that control the mixed directional familywise error rate, which is the probability of making any type 1 or type 3 (directional)

BACKGROUND It has been suggested that similarity searching using 2D fingerprints may not be suitable for scaffold hopping. METHODS This article reports a detailed evaluation of the effectiveness of six common types of 2D fingerprints when they are used for scaffold-hopping similarity searches of the Molecular Design Limited Drug Data Report database, World of Molecular Bioactivity database an...

In this paper, we consider the problem of simultaneously testing many two-sided hypotheses when rejections of null hypotheses are accompanied by claims of the direction of the alternative. The fundamental goal is to construct methods that control the mixed directional familywise error rate, which is the probability of making any type 1 or type 3 (directional)

In this paper we study standard graded artinian level algebras, in particular those whose socle-vector has type 2. Our main results are: the characterization of the level h-vectors of the form (1, r, ..., r, 2) for r ≤ 4; the characterization of the minimal free resolutions associated to each of the h-vectors above when r = 3; a sharp upper-bound (under certain mild hypotheses) for the level h-...

An almost square of type 2 is an integer n that can be factored in two different ways as n = a1b1 = a2b2 with a1, a2, b1, b2 ≈ √ n. In this paper, we shall improve upon our previous results on short intervals containing such an almost square. This leads to another question of independent interest: given some 0 < c < 1, find a short interval around x which contains an integer divisible by some i...