The objective was to assess the efficacy of coenzyme Q10 as a preventive treatment for migraine headaches. Thirty-two patients (26 women, 6 men) with a history of episodic migraine with or without aura were treated with coenzyme Q10 at a dose of 150 mg per day. Thirty-one of 32 patients completed the study; 61.3% of patients had a greater than 50% reduction in number of days with migraine heada...

The processes of aging and photoaging are associated with an increase in cellular oxidation. This may be in part due to a decline in the levels of the endogenous cellular antioxidant coenzyme Q10 (ubiquinone, CoQ10). Therefore, we have investigated whether topical application of CoQ10 has the beneficial effect of preventing photoaging. We were able to demonstrate that CoQ10 penetrated into the ...

Introduction Coenzyme Q10 (CoQ10) is a compound found naturally in virtually every cell in the human body. Because of its ubiquitous presence in nature and its quinone structure (similar to that of vitamin K), CoQ10 is also known as ubiquinone. CoQ10 is a fat-soluble substance whose primary role is as a vital intermediate of the electron transport system in the mitochondria. Adequate amounts of...

Coenzyme Q10 (CoQ10) or ubiquinone is one of the two electron carriers in the mitochondrial respiratory chain which has an essential role in the process of oxidative phosphorylation. Defects in CoQ10 synthesis are usually associated with the impaired function of CoQ10-dependent complexes I, II and III. The recessively transmitted CoQ10 deficiency has been associated with a number of phenotypica...

BACKGROUND Insulin-like growth factor-1(IGF-1) has a multitude of effects besides cell growth and metabolism. Reports also indicate anti-inflammatory and antioxidative effects. The concentrations of IGF-1 decrease with age and during inflammation. As selenium and coenzyme Q10 are involved in both the antioxidative defense and the inflammatory response, the present study aimed to examine the eff...

CoQ10 was discovered by Dr. Frederick L. Crane at the University of Wisconsin in the late 1950s during his research on the biochemistry of the mitochondrial electron transport chain, also known as the respiratory chain. The pure substance isolated from beef heart mitochondria was sent to Dr. Karl Folkers at the pharmaceutical company Merck for identification and elucidation of its structure. It...

While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a n...

BACKGROUND Ischemia and subsequent reperfusion induce lipid peroxidation in the cerebrum of the fetal rat. The present study evaluated the antioxidant activity of endogenous coenzyme Q in protecting against the lipid peroxidation induced in the fetal rat brain by ischemia/reperfusion. METHODS We used wistar rats at day 19 of pregnancy. Fetal ischemia was induced by bilateral occlusion of the ...

Coenzyme Q 9 (CoQ 9) in human plasma may originate as a product of incomplete CoQ 10 biosynthesis or from the diet. The estimated dietary CoQ 9 intake is 0 –1.3 ␮mol/day, primarily from cereals and fats (1, 2), but this is unreliable because many food items contain levels below the detection limit (1). Some methods for estimating human plasma CoQ 10 use CoQ 9 as an internal standard; thus, intr...

Background: In-situ preservation of cauda epididymal spermatozoa at -10 degree centigrade with electrolyte free media for obtaining maximum functional gametes than preservation at 5 degree centigrade. Materials and Methods: Electrolyte free media prepared with soybean lecithin-glycerol, Coenzyme Q10 - glycerol and soybean lecithin - Coenzyme Q10- glycerol were inoculated separately into ligated...