BACKGROUND AND PURPOSE Atherosclerotic carotid plaque ulceration is considered a marker of previous plaque rupture and subsequent thromboembolism. It can be accurately detected with multidetector CTA. We hypothesized that atherosclerotic plaque ulceration is associated with nonlacunar ischemic stroke rather than lacunar stroke. METHODS Prospectively, 750 consecutive patients with transient is...

Background and Aims: Patients with FH showed impaired immunosuppressive response associated increased inflammation. We tested Adoptive Cell Therapy (ACT) Treg engineered to selectively migrate in the atherosclerotic plaque dampen immune-inflammatory arterial wall.

Fibromuscular Dysplasia of the Extracranial Internal Carotid A rteries Associated With an Ulcerative Plaque • Fibromuscular dysplasia (FMD) of the extracranial internal carotid arteries is a relatively rare angiographical finding which has been reported as an incidental finding during angiography, as well as in association with a variety of different clinical conditions. A case is reported of t...

OBJECTIVE The atherosclerotic plaque that is vulnerable to rupture and to superimposed thrombosis is mainly represented by a thin-cap fibroatheroma with or without ulceration/thrombosis and inflammatory infiltrates. Total serum gamma-glutamyltransferase (GGT) activity is an independent predictor for cardiovascular events. Four GGT fractions have been identified in plasma and only one of them (b...

= Abstract =Cholesterol embolization is one of the serious complications of ulcerative atheromatous plaque. Ischemic changes in the lower extremity, brain and other organs including the kidney, pancreas and gastrointestinal tract due to atherosclerotic microemboli have been well documented in autopsy cases in the western world. However, it has been seldom reported in the Korean literature. We r...

BACKGROUND The hallmark of atherosclerosis is the accumulation of plaque in vessel walls. This process is initiated when monocytic cells differentiate into macrophage foam cells under conditions with high levels of atherogenic lipoproteins. Vulnerable plaque can dislodge, enter the blood stream, and result in acute myocardial infarction and stroke. Imaging techniques such as cardiovascular magn...

A number of microRNAs (miRs) have been shown to participate in the regulation of vascular smooth muscle cell (VSMC) proliferation, a key step in the formation of atherosclerotic plaque, by targeting certain genes. The aim of the present study was to investigate the roles of miR‑146a and miR‑21 in VSMC growth and to study the underlying mechanisms. The expression levels of four previously report...

BACKGROUND Neointimal inflammation and angiogenesis are important contributors of progression and destabilization of the atherosclerotic plaque. While the role of vascular endothelial growth factor (VEGF) and its receptors VEGF-R1 (Flt-1) and VEGF-R2 (Flk-1) in this process has clearly been defined, expression of the VEGF-R3 (Flt-4) has only been documented on lymphatic and tumor endothelium. T...

Background High-resolution CE-MRI is a noninvasive imaging modality to monitor the progression and regression of atherosclerotic plaque and disruption. The purpose of this study is to monitor the progression of atherosclerotic plaque in rabbit model with serial high-resolution contrast enhancement MRI (CE MRI), and sought to differentiate the morphology and composition between ruptured and non-...

A strong relationship exists between the severity of carotid stenosis and early stroke risk. Inflammation is believed to be an important event for atherosclerotic plaque destabilization and subsequent thromboembolism. (18)F-FDG can image atherosclerotic inflammation, providing information about plaque biology, which may serve as a useful biomarker for the assessment of early stroke risk.