Inflammatory bowel diseases are associated with increased risk for thrombotic complications, In patients with ulcerative colitis (UC) cerebral sinus venous thrombosis (CSVT) is an extremely rare complication. We report a patient with active UC and CSVT. The patient was heterozygous for Factor V Leiden and G20210A prothrombin gene mutations without other identifiable precipitating factors. This ...

OBJECTIVES To compare the efficacy of heparin in ulcerative colitis (UC) as demonstrated in observational studies and controlled clinical trials. INTRODUCTION Ulcerative colitis (UC) is a chronic condition with a relapsing and remitting course. Several studies have been conducted (observational and controlled clinical trials) to test the usefulness of heparin in this condition but the results...

BACKGROUND Ulcerative colitis (UC) is characterized by an energy deficiency state of the colonic epithelium. This study evaluated mitochondrial electron transport chain (ETC) complex activity in normal and disease mucosa in patients with UC. Alterations in ETC complexes were also investigated in experimental colitis in mice. METHODS Biopsies were obtained from macroscopically normal and disea...

Inflammatory bowel disease (IBD) consists predominantly of ulcerative colitis (UC) and Crohn’s disease (CD), which are clinically distinguished by intestinal localization, local features of inflammation, a profile of complications, and familial aggregation. UC is characterized by recurring episodes of continuous inflammation limited to the mucosal layer of the colon and rectum, and approximatel...

The association between ulcerative colitis (UC) and colorectal cancer (CRC) was first reported in the 1920s (Crohn & Rosenberg, 1925). Since then, numerous studies have confirmed the overall risk of developing colorectal cancer associated with UC, and inflammatory bowel disease (IBD) in general. Many studies incorporate both UC and Crohn’s colitis together with regards to their risk of colorect...

Ulcerative colitis (UC) is characterized by presence of ulcer in colon and bloody diarrhea. The present study explores the possibility of association between Salmonella and ulcerative colitis. The present study comprised 59 cases of UC, 28 of colon cancer (CC), 127 of irritable bowel syndrome (IBS), and 190 of healthy control. The serological study was done by Widal and Indirect Haemagglutinati...

BACKGROUND & OBJECTIVES Oxidative stress contributes to severity of ulcerative colitis (UC) but the status of erythrocyte antioxidant defence remains unknown. The present study was aimed to study the role of oxidative stress and antioxidant levels in erythrocytes of UC patients from north India. METHODS A total of 81 adult UC patients and 85 age and sex matched apparently healthy controls wer...

Ulcerative colitis (UC) is a chronic inflammatory condition of unclear etiology affecting the large bowel, most commonly the rectum and extending proximally in a continuous fashion. The overall principle in the pathophysiolgy of ulcerative colitis is the dysregulation of the normal immune system against an antigenic trigger leading to a prolonged mucosal inflammatory response. The diagnosing of...

• Thiamine deficiency is an indirect complication of inflammatory bowel disease. Acute and severe thiamine leads to Wernicke's encephalopathy. Parenteral in people with disease who are weakened necessary for prevention Treatment encephalopathy 500 mg thiamine, three times per day, parenteral, until symptoms resolve. Crohn's (CD) ulcerative colitis (UC) chronic debilitating conditions the gastro...

Abstract Background Symptoms of ulcerative colitis (UC) negatively affect patients’ health-related quality life (HRQoL). The aim this study was to identify symptoms and impacts experienced by patients with UC, develop a conceptual model (CM) evaluate available patient-reported outcome (PRO) measures for appropriateness inclusion in UC clinical studies. Methods We conducted landscape assessment ...