A Cu-catalyzed new sequence involving the Ullmann type intermolecular C-C followed by an intramolecular C-N coupling and then intramolecular aza-Michael type addition (and oxidation) in a single pot afforded various fused N-heterocyclic acetic acid derivatives as inhibitors of PDE4.

Magnetic nanoparticle-supported proline ligand was prepared and used for the CuI catalyzed Ullmann-type coupling reactions of aryl/heteroaryl bromides with various nitrogen heterocycles to form the corresponding N-aryl products in good to excellent yields; furthermore, this magnetic nanoparticle-supported proline ligand could be readily separated using an external magnet and reused without sign...

James S. Gill,* Amy J. Ullmann,† Amanda D. Loftis,‡ Tom G. Schwan,§ Sandra J. Raffel,§ Merry E. Schrumpf, § and Joseph Piesman† *Iowa State University, Ames, Iowa, USA; †Centers for Disease Control and Prevention, Fort Collins, Colorado, USA; ‡Centers for Disease Control and Prevention, Atlanta, Georgia, USA; and §Rocky Mountain Laboratories of National Institutes of Health, Hamilton, Montana, USA

Surfactant-free, single-nano-sized copper nanoparticles (Cu NPs) (size: about 2 nm) were prepared by the DMF reduction method. The Cu NPs showed high catalytic activity (with a turnover number (TON) of up to 2.2 × 10(4)) in Ullmann-type cross-coupling of aryl halides with phenols under ligand-free conditions.

A series of porphyrin-based porous organic polymers (PPOPs) were synthesized in excellent yields via the Yamamoto−Ullmann couplings of tetrabromo spirobifluorene with several brominated porphyrin monomers. After isolation and demetalation, the metal-free PPOP can be postsynthetically metalated to form a Mn−PPOP that is catalytically active toward the selective double-epoxidation of divinylbenze...

A number of novel benzimidazole derivatives 1-4 were synthesized and the catalytic activity of these compounds in a catalytic system consisting of a benzimidazolium salt/Pd(OAc)2/K2CO3 were investigated in the Suzuki-Miyaura and Ullmann type homocoupling reactions under microwave irradiation. We obtained both cross coupling and homocoupling products of pyridine and some side products such as di...

Readily accessible tartramide ligands have been demonstrated to promote copper-catalysed N-arylation under mild conditions. In addition, the coupling protocol employs cheap and readily available pre-catalyst, ligand, base (NaOH), overcomes many current limitations often associated with Ullmann coupling: it can be run low catalyst loadings, does not require use of excess amine, operates at room ...