نتایج جستجو برای: unbound aggregate
تعداد نتایج: 49655 فیلتر نتایج به سال:
Saturated hydraulic conductivity (Ks) is one of the most important soil physical characteristics that plays a major role in the soil hydrological behaviour. It is mainly affected by the soil structure characteristics. Aggregate size distribution is a measure of soil structure formation that can affect Ks. In this study, variations of Ks were investigated in various aggregate size distributions ...
The unbound serum concentration of valproic acid (VPA) is closely related to its therapeutic efficacy. In epileptic infants, the unbound VPA concentration varies largely from patient to patient, being difficult to predict using the reported equations for older children. To establish an equation to estimate the unbound concentration in infants, we empirically characterized the relationship betwe...
aggregate stability is an important soil property because it dictates how strongly a soil can resist water erosion. the objectives in this study were: (1) to compare the stability of six soil aggregate size fractions, primarily to determine if aggregate stability varies with aggregate size, and (2) to determine with which aggregate size fraction the stability of most soils would be different fr...
Disopyramide exhibits concentration-dependent binding to plasma proteins at therapeutic plasma concentrations. This paper reviews the effect of this type of binding on both the pharmacokinetic and pharmacodynamic properties of the drug. For a drug with capacity-limited, binding-sensitive elimination like disopyramide, concentration-dependent binding to plasma proteins produces a non-linear rela...
Compacted unbound granular materials are extensively used as sub-layer in pavement design. Most pavement design guides assume that they are responsible for the degradation and deformation of the roads and railways that they support. Biaxial tests are usually employed to investigate the elasto-plastic response of these materials to cyclic loading. A particularly interesting question is whether a...
PURPOSE This study was designed to evaluate whether less frequent dosing [three times per week (TIW) or once weekly (QW)] of 150 mg vismodegib following a loading dose [150 mg once daily (QD) for 11 days] would result in similar safety, tolerability, and steady-state levels of total and unbound vismodegib as continuous QD dosing. EXPERIMENTAL DESIGN Sixty-seven patients with advanced solid tu...
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