one of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. we report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. chromosomal studies were performed on the basis of g-banding technique at high resolution and revealed 46, xx, t (16 6) (p12 q26) and 46, x...

Recurrent spontaneous abortion (RSA) is defined as the loss of pregnancy for at least two respectively times before fetus reaches twenty-four week pregnancy, and its causes are multiple, some which known, but 50% them still unexplained. Antiphospholipid syndrome (APS), one autoimmune diseases that can cause blood clots lead to abortionor in first trimester pregnancy. The study included 44 women...

prevalence of abortion is higher in women with autoimmune thyroid disease. in the majority of cases, however, no abnormality of thyroid function is detected despite the high levels of antithyroid antibodies. the direct influence of such harmful autoantibodies in female reproductive organs may serve a role in pregnancy loss. in this study, expression of thyroglobulin in the reproductive tissues ...

background: chromosomal disorders are the most common cause of first trimester spontaneous abortion. among the human chromosomes, chromosome no.9 was the most common structural chromosomal variant and it is not thought to be of any functional importance, which often considers as a normal variation in structural polymorphisms, nevertheless there are some studies which claim that there is an asso...

Background: To determine the incidence of an abnormal glucose tolerance test in patients with recurrent spontaneous abortion and whether metformin would safely reduce the rate of first trimester spontaneous abortions in patients without polycystic ovary syndrome (PCOS) as well as with PCOS and an abnormal glucose tolerance test. Materials and Methods: Patients with a history of recurrent sponta...

BACKGROUND Inherited thrombophilias are the leading cause of maternal thromboembolism and are associated with an increased risk of recurrent spontaneous abortion (second- and third-trimester fetal loss). The purpose of this study was to investigate the effects of factor V and factor II involved in reproductive failure. Recently a possible association between unexplained infertility and genetic ...