BACKGROUND Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA) have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition of the uterus may also affect sperm qualities. OBJECTIVE The objectives of this study were to search if these sera could induce DNA denaturation in sperm nucle...

In a case-control study of 73 women with and 141 women without spontaneous abortion, the authors determined the activity of the three principal caffeine-metabolizing enzymes--cytochrome P-4501A2 (CYP1A2), xanthine oxidase, and N-acetyltransferase 2--by measuring levels of caffeine metabolites in urine. After examining the effect of enzyme activity and different levels of caffeine intake, they c...

Abstract Background : To investigate the associations of serum vitamin D and Fok I polymorphism its receptor (VDR) with unexplained recurrent spontaneous abortion (URSA). Methods Ninety URSA patients another 104 healthy pregnant women were selected as control groups, respectively. 25-Hydroxyvitamin [25-(OH)D] level was detected by chemiluminescence. VDR gene analyzed PCR, distribution genotype ...

UNLABELLED Human reproduction is not considered a highly efficient biological process. Before the end of the first trimester, 30%-50% of conceptions end in spontaneous abortion. Most losses occur at the time of implantation. 15%-20% of clinical pregnancies end in spontaneous abortions. Recurrent pregnancy loss is a frustrating clinical problem both for clinicians and patients. Recurrent pregnan...