Clostridium difficile strain ribotype 027 is a hypervirulent pathogen that is responsible for recent, severe outbreaks of serious nosocomial infections. As a foundation for the development of a preventative carbohydrate-based vaccine, we have synthesized a pentasaccharide cell wall repeating unit from PS-I unique to this strain, by the linear assembly of four monosaccharide building blocks.

1Global Vaccine Development, GlaxoSmithKline Vaccines, 1300 Wavre, Belgium 2Department of Pathophysiology and Transplantation, University of Milan and Fondazione IRCCS Cà, Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy 3Paediatric Infectious Diseases, Infection Control and Epidemiology Unit, Université Libre de Bruxelles, 1020 Brussels, Belgium 4Multi-Centre Otitis Media Study Group, ...

Vaccine hesitancy is a global threat to public health contributed by misinformation and lay beliefs about diseases health. Our study aimed assess preparedness intent receive COVID-19 vaccine among healthcare workers in single institution northwest Malaysia the feasibility efficacy of our mobile education programme overcome workers. initial survey 1,616 respondents found that 25.3% either refuse...

1 Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom, 2 Immunisation, Hepatitis and Blood Safety Department, Public Health England, London, United Kingdom, 3 Immunobiology Unit, University College London, London, United Kingdom, 4 International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Ma...

1Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA; 2Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 3Medical Biotechnology Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani, Thailan...

From the * Thymus Biology Unit, The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia; ‡ Cooperative Research Centre for Vaccine Technology at the Queensland Institute of Medical Research, The Royal Brisbane Hospital, Herston, QLD 4029, Australia; and § The Monash Medical School, Alfred Hospital, Prahran, Victoria 3181, Australia

Methods: PRRS vaccine was administered and unidirectional pig flow was used in a finishing pig unit to establish a noninfected population. After the protocol was completed, seronegative nursery pigs were introduced to the facility on a monthly basis, and their serostatus was monitored over a 4-month period. Previously infected and/or vaccinated pigs co-existed in the same airspace throughout th...

BACKGROUND Little is known on the effectiveness of influenza vaccine in ESRD patients. This study compared the incidence of hospitalization, morbidity, and mortality in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD) between cohorts with and without influenza vaccination. METHODS We used the insurance claims data from 1998 to 2009 in Taiwan to determine the incidence of t...

OBJECTIVE In India, Haemophilus influenzae type b (Hib) vaccine introduction in the universal immunization programme requires evidence of its potential health impact and cost-effectiveness, as it is a costly vaccine. Since childhood mortality, vaccination coverage and health service utilization vary across states, the cost-effectiveness of introducing Hib vaccine was studied in Haryana state. ...

Breast screening appointments should be scheduled to take place before women receive a first dose of covid-19 vaccine or four six weeks after the second when possible, Drug Safety Research Unit has said.1 The advice been given because potential for swelling lymph nodes in one armpit (the side injection) following vaccination, which could detected …