The detection of nucleobases in carbonaceous chondrites such as Murchison supports the scenario in which extraterrestrial organic molecules could have contributed to the origin of life on Earth. However, such large molecules have not been observed to date in astrophysical environments, in particular, comets and the interstellar medium (ISM). The physico-chemical conditions under which nucleobas...

In the course of work now in progress on the determination of constitution of nucleic acid and its primary hydrolytic products-neucleotides and neucleosides-it has finally become necessary to develop and utilize a new method for introducing methyl radicals into pyrimidine and purine combinations. The alkylation methods generally employed for bringing about such changes, namely, by interaction o...

Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 3 of the six-member ring. Three nucleobases found in nucleic acids, cytosine (C), thymine (T), uracil (U), are pyrimidine derivatives. A has many properties common with as number ring increases pi electrons become less energetic electrophilic substitution gets mor...