Anaplastic histology and metastasis are each associated with higher relapse and mortality rates in Wilms tumor patients. However, not all anaplastic tumors relapse and some nonanaplastic tumors relapse unexpectedly. To identify more accurate early prognostic indicators, we analyzed expression of 4,900 cancer-related genes in 26 primary Wilms tumors. This analysis revealed that expression of a s...

Anaplastic histology and metastasis are each associated with higher relapse and mortality rates in Wilms tumor patients. However, not all anaplastic tumors relapse and some nonanaplastic tumors relapse unexpectedly. To identify more accurate early prognostic indicators, we analyzed expression of 4,900 cancer-related genes in 26 primary Wilms tumors. This analysis revealed that expression of a s...

1. Webber BL, Parham DM, Drake LG, et al. Renal tumors in childhood. Pathol Ann Part 1992;1:191–232. 2. Murphy WM, Beckwith JB, Farrow GM. Tumors of the kidney, bladder and related urinary structures. In: Murphy WM, Beckwith JB, Farrow GM, editors. Atlas of tumor pathology, series 3, fascicle 11. Washington D.C.: Armed Forces Institute of Pathology, 1994. 3. Beckwith JB. Pediatric neoplastic di...

CONTEXT Mutations of the p53 tumor suppressor gene are the most frequent alterations observed in human neoplasias affecting adults. In pediatric oncology, however, they have seldom been identified. Wilms' tumor is a renal neoplasia commonly occurring in children and is associated with mutations of the WT1 gene. The correlation between Wilms' tumor and alterations of the p53 gene has not been we...

OBJECTIVE To evaluate treatment outcomes in Wilms' tumor (WT). MATERIALS AND METHODS We studied 53 children with median age of 2 years with WT, stages I-19, II-14, III-12, IV-6 and V-2. Treatment consisted of surgical excision plus adjuvant (40 children) or neoadjuvant and adjuvant chemotherapy (unresectable tumor, n=8, or caval tumor extension, n=5). Chemotherapy and radiotherapy followed pr...

: Wilms tumor (WT) is the most frequent renal of childhood and a highly responsive to chemotherapy. P53 ki67 are two important markers that have been evaluated in many cancers. The role p53 pathogenesis progression WT only partly understood. Over past decade, importance Ki-67