BACKGROUND Colorectal, endometrial and upper urinary tract tumours are characteristic for Lynch syndrome (hereditary non-polyposis colon carcinoma, HNPCC). The aim of the present study was to establish whether carriers of mutations in mismatch repair genes MLH1, MSH2 or MSH6 are at increased risk of urinary bladder cancer. METHODS Carriers and first degree relatives of 95 families with a germ...

Compromised activity of the DNA repair enzymes may raise the risk of a number of cancers. We analyzed polymorphisms in the Xeroderma Pigmentosum, Complementation Group C (XPC) gene for their correlation with urinary bladder cancer. Ala499Val and Lys939Gln polymorphisms were genotyped in 234 urinary bladder cancer cases and 258 control samples. A significant association between Ala499Val polymor...

Received June 2008 Accepted August 2008 INTRODUCTION Pelvic irradiation is known to cause several complications involving urinary bladder such as radiation cystitis, ulceration, and incontinence.(1,2) Spontaneous intraperitoneal rupture of the urinary bladder is a rare complication following pelvic irradiation.(3-5) To the best of our knowledge, there is only one report of radiation-induced bla...

PURPOSE The aim of this study was to identify noninvasive pharmacodynamic biomarkers of FGFR3-targeted therapies in bladder cancer to facilitate the clinical development of experimental agent targeting FGFR3. EXPERIMENTAL DESIGN Potential soluble pharmacodynamic biomarkers of FGFR3 were identified using a combination of transcriptional profiling and biochemical analyses in preclinical models....

background : e-cadherin is a trans-membrane glycoprotein that plays a critical role in many aspects of cell adhesion as well as establishment and maintenance of epithelial cell polarity. loss of the adhesive function of e-cadherin seems to promote invasive and metastatic properties of neoplastic cells.   objectives: the present study is a retrospective study aiming to evaluate the loss of e-cad...

Bladder cancer is a common malignancy of the urinary tract, which generally develops in the epithelial lining of the urinary bladder. The specific course of treatment depends on the stage of bladder cancer; however, therapeutic strategies typically involve intravesical drug delivery to reduce toxicity and increase therapeutic effects. Recently, metallic, polymeric, lipid, and protein nanopartic...

Background: Several studies link urinary tract infection (UTI) and bladder cancer. However, the association between cancer muscle invasiveness incidence of UTI is not known Objective: This study aimed to occurrence in severity cancer, specifically a patient admitted Karawang regional hospital, Indonesia. Material Methods: single-center retrospective case control. Data were obtained through medi...

OBJECTIVE Noninvasive biomarkers are used routinely in the clinical management of several cancers but bladder cancer detection and surveillance remains dependent on invasive procedures such as cystoscopy. No validated biomarker currently exists in routine clinical practice other than cytology. Gene-based testing has shown great promise for biomarker profiling and this review addresses the curre...

Bladder cancer occurs after the fifth decade and more frequently in men than in women (sex ratio 2:1 to 3:1). It has been associated mainly with smoking, but also with occupational exposure to carcinogens from aniline dyes, paints, rubber, etc, and chronic irritation of the bladder mucosa due to bladder stones, or schistosomiasis. The main symptom is painless hematuria, which in the adult patie...

INTRODUCTION Bladder calculi account for 5% of all urinary system calculi. They are usually seen in older men and occur because of infravesical obstructions such as prostate hyperplasia, neurogenic bladder, urinary tract infection (UTI), foreign bodies, but anti-incontinence surgery in woman and rarely pregnancy can also be predisposing factors for bladder calculus. Bladder stones could also be...