BACKGROUND The response rate in the pharmacological treatment of depression has been estimated to be around 50%, achieving a remission in symptomatology in only one third of the patients. Suboptimal prescription of antidepressants has been proposed as a significant explanatory factor for this therapeutic inefficacy. The use of pharmacogenetic testing might favor the optimization of pharmacother...

This paper is devoted to noisy optimization in case of a noise with standard deviation as large as variations of the fitness values, specifically when the variance does not decrease to zero around the optimum. We focus on comparing methods for choosing the number of resamplings. Experiments are performed on the differential evolution algorithm. By mathematical analysis, we design a new rule for...

The operating system’s role in a computer system is to manage the various resources. One of these resources is the CPU (Central Processing Unit). It is managed by a component of the operating system called the CPU scheduler. Schedulers are optimized for typical workloads expected to run on the platform. However, a single scheduler may not be appropriate for all workloads. That is, a scheduler m...

We introduce a new class of compiler heuristics: hybrid optimizations. Hybrid optimizations choose dynamically at compile time which optimization algorithm to apply from a set of different algorithms that implement the same optimization. They use a heuristic to predict the most appropriate algorithm for each piece of code being optimized. Specifically, we construct a hybrid register allocator t...

Newton’s method is a basic tool in numerical analysis and numerous applications, including operations research and data mining. We survey the history of the method, its main ideas, convergence results, modifications, its global behavior. We focus on applications of the method for various classes of optimization problems, such as unconstrained minimization, equality constrained problems, convex ...

The Use of Traces in Optimization by Borys Jan Bradel Master of Applied Science Edward S. Rogers Sr. Department of Electrical and Computer Engineering University of Toronto 2004 This is the abstract.