BACKGROUND Perivascular epithelioid cell tumor (PEComa) is a rare subtype of mesenchymal origin tumor composed of epithelioid cells which exhibits immunohistochemical co-expressions of melanocytic markers and smooth muscle markers. CASE PRESENTATION In the first case, malignant uterine PEComa with vaginal and multiple lung metastasis was misdiagnosed preoperatively as uterine leiomyosarcoma d...

Based on traditional reports, the aqueous and ethanol extracts of the leaves of N. laevis were tested on isolated uterine preparations of non-pregnant rats. The effects of increasing cumulative concentrations of the extracts on the amplitude and frequency of spontaneously contracting uterine tissues were tested. Direct effects of the extracts and acetylcholine on uterine smooth muscle were also...

Human uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker, whi...

The variety of factors controlling the onset of parturition, äs well äs the very complex mechanisms which physiologically maintain pregnancy by inhibiting uterine contractions are only partially understood today. As long äs the triggering mechanisms, and the conditions favoring timely and early labor are incompletely known, symptomatic therapeutic attempts aim at blocking unwanted contractile a...

The incidence of primary malignant lymphoma arising in the female genital tract is extremely rare and constitutes approximately 0.05% of malignant tumors. Uterine malignant lymphoma develops in the endometrial stroma, causing minimal necrosis. It is therefore difficult to diagnose malignant lymphoma, as it does not involve genital bleeding or epithelial defects. We have performed transcervical ...

Fibroid is the commonest benign neoplasm of the uterus in females, composed of smooth muscle with variable amount of fibrous connective tissue, hence named as leiomyoma or fibromyoma. It is the commonest of all pelvic tumours in females, excluding pregnancy; being more common in nulliparous. It can be intra uterine / extra uterine. Extrauterine fibroids though do occur, but are not as common as...

AIMS Well-differentiated leiomyosarcomas show morphologically recognizable smooth muscle differentiation, whereas poorly differentiated tumours may form a spectrum with a subset of undifferentiated pleomorphic sarcomas. The expression of certain muscle markers has been reported to have prognostic impact. We investigated the correlation between the morphological spectrum and the muscle marker ex...

Uterine myomas represent one of the most common female pathologies. Uterine smooth muscle myomas or fibromas are benign tumours which respond to hormones and their etiology induces wide interest. The myomas were found to contain aromatase and, in addition, cells of the myomas were found to synthesize estrogen. This study was conducted on patients with the myomas, in either generative age or in ...

Abnormalities in uterine contractility are thought to contribute to several clinical problems, including preterm labor. A better understanding of the mechanisms controlling uterine activity would make it possible to propose more appropriate and effective management practices than those currently in use. Recent advances point to a role of the protein kinase C (PRKC) family in the regulation of u...