In this study, we examined the protective effects of porphyra-334 against UVA-irradiated cellular damage and elucidated the underlying mechanisms. Porphyra-334 prevented UVA-induced cell death and exhibited scavenging activities against intracellular oxidative stress induced by UVA irradiation in skin fibroblasts. We found that porphyra-334 significantly reduced the secretion and expression of ...

Long-wave UVA is the major component of terrestrial UV radiation and is also the predominant constituent of indoor sunlamps, both of which have been shown to increase cutaneous melanoma risk. Using a two-chamber model, we show that UVA-exposed target cells induce intercellular oxidative signaling to non-irradiated bystander cells. This UVA-mediated bystander stress is observed between all three...

We carried out a randomized, double-blind, placebo-controlled study to examine the therapeutic effect of UVA-1 irradiation on dyshidrotic hand eczema. Twenty-eight patients were randomised to receive UVA-1 irradiation (40 J/cm2) or placebo, five times a week for 3 weeks. Evaluated by the DASI and the VAS, UVA-1 was significantly more effective after 2 and 3 weeks. Also, desquamation and area of...

Ultraviolet A (UVA) radiation represents more than 90% of the solar UV radiation reaching Earth's surface. Exposure to solar UV radiation is a major risk in the occurrence of non-melanoma skin cancer. Whole genome sequencing data of melanoma tumors recently obtained makes it possible also to definitively associate malignant melanoma with sunlight exposure. Even though UVB has long been establis...

Immunosuppressive doses of solar-simulated UV radiation activate lymph node B cells that can suppress primary immunity by inhibiting the function of dendritic cells. The aim of this study was to determine the waveband responsible for activation of these suppressor B cells. We exposed C57BL/6 mice to various doses of either UVA or UVB radiation and analyzed the number and activation state of lym...

introduction: palmoplantar psoriasis could hardly be differentiated from chronic tylotic eczema both clinically and histologically. the most commonly used therapeutic options for palmoplantar psoriasis are long-term therapy with topical corticosteroids and local puva. frequently, it is a recalcitrant disease. we investigated the efficacy  and tolerability of the combination of topical calcipotr...

objective: methoxsalen is a natural photoactive compound which is found in many seed plants. a number of epidermal proliferative disorders can be treated by methoxsalen along with long wave ultraviolet a (uva). materials and methods: in an experimental study, we aimed to demonstrate the effect of methoxsalen, uva and their combination on oogenesis balb/c mice. there were two experimental groups...

High-energy wavelengths in the ultraviolet-B (UVB, 280-315 nm) and the UVA (315-400-nm) portion of the spectrum are harmful to terrestrial and aquatic organisms. Interestingly, UVA is also involved in the repair of UV induced damage. Organisms living in shallow coral reef environments possess UV absorbing compounds, such as mycosporine-like amino acids, to protect them from UV radiation. While ...

The UVB emission from ten different types of 'UVA fluorescent lamp' has been measured by spectroradiometry. The mean ratio of UVB emission to UVA emission was found to be 0.94 +/- 0.35 (1 SD)%. By weighting the spectral irradiance of each lamp by the DIN standard erythemal curve, the mean erythemally effective UVB emission (normalised to 297 nm), expressed as a percentage of the UVA emission, w...

PURPOSE Combined riboflavin/UVA treatment inducing collagen cross-links in the cornea has been shown to increase the biomechanical rigidity of the cornea and has been used successfully in the treatment of progressive keratoconus. The current study was undertaken to investigate the possible cytotoxic effect of combined riboflavin/UVA treatment on corneal keratocytes in vivo. METHODS Thirty-fou...