The recombinant hemagglutinin (rHA)-based influenza vaccine Flublok® has recently been approved in the United States as an alternative to the traditional egg-derived flu vaccines. Flublok is a purified vaccine with a hemagglutinin content that is threefold higher than standard inactivated influenza vaccines. When rHA derived from an H3N2 influenza virus was expressed, purified, and stored for 1...

Since July 1885, when Louis Pasteur first vaccinated a human subject against rabies, various different types of vaccines have been developed in an effort to find a biological product that will elicit a potent and assured immune response while causing minimal sideeffects, discomfort, and expense. The most important of these vaccines use antigen obtained from nerve tissues, bird embryos, and (in ...

Immunization is an important cost effective strategy for child survival(l,2). With the inclusion of heat labile oral polio and measles vaccine in the Universal Immunization Programme, maintenance of cold chain is of paramount importance(3). Inadequate management of cold chain may reduce the potency of the oral polio vaccine to almost zero. In India 15 to 30% cases of poliomyelitis, occur in chi...

Factors involved in the development of a human oncornavirus vaccine are discussed. The isolation and purification of subviral gp69/71 antigenic components enhance the feasibility of developing safe vaccine. The recent isolation of a C-type virus (the HL-23) from a human leukemic patient and its similarity to the simian sarcoma virus presents us with a unique opportunity to test the safety and p...

Pittman, Margaret (National Institutes of Health, Bethesda, Md.), and Howard J. Bohner. Laboratory assays of different types of field trial typhoid vaccines and relationship to efficacy in man. J. Bacteriol. 91:1713-1723. 1966.-Antibody responses of rabbits to H, O, and Vi antigens did not differentiate vaccine K (acetone-killed and dried) from vaccine L (heat-phenolized and dried) relative to ...

Melanoma antigen-encoding gene 3 (MAGE-3) is an ideal candidate for a tumor vaccine although its potency need to be increased. Heat shock proteins (HSPs) represents a potential approach for increasing the potency of DNA vaccines. In the present study, a fusion DNA vaccine composed of Mycobacterium tuberculosis HSP70 and MAGE-3 was constructed and used to immunize C57BL/6 mice against B16 or B16...