BACKGROUND Various methods are used for cervical ripening during the induction of labour. It is still debatable which of these methods of treatment is optimal. OBJECTIVE To compare treatment techniques for cervical ripening in the induction of labour. SEARCH STRATEGY Medline, Embase, and the Cochrane Collaboration databases were searched using the keywords 'cervical ripening', 'labour induc...

a comparative study of vaginal misoprostol plus oxytocin and oxytocin alone in the preparation and induction of labor in the third trimester of pregnancy     bahadori f [1] , behroozilak t [2] *, bromand f [3] , nanbakhsh f [4]     received: august 27, 2011 accepted: october 7, 2011     abstract   background & aims : induction of labor with an unfavorable cervix is one of the common reasons of ...

OBJECTIVE To compare the effectiveness of oral misoprostol with vaginal misoprostol as a cervical priming agent prior to first trimester vacuum aspiration. DESIGN Randomised study. SETTING Scottish teaching hospital. POPULATION Primigravid women at gestations up to 91 days requesting surgical abortion under the 1967 Abortion Act. METHODS Sixty-four women were randomised to receive misop...

OBJECTIVES To compare the efficacy of labour induction using sublingual misoprostol versus combined artificial rupture of membranes and oxytocin infusion for nulliparous women with a favourable cervix at term. DESIGN Open randomised controlled trial. SETTING Regional hospital, Hong Kong. PATIENTS Fifty nulliparous women with a favourable cervix (Bishop score 6 or more) at term and indicat...

This paper sought to determine the safety and feasibility of home-based prophylaxis of postpartum hemorrhage (PPH) with misoprostol, including assessment of the need for referrals and additional interventions. In rural Tigray, Ethiopia, traditional birth attendants (TBAs) in intervention areas were trained to administer 600mcg of oral misoprostol. In non-intervention areas women were referred t...

BACKGROUND New indications for misoprostol include medical abortion, cervical softening, induction of labor and treatment of postpartum hemorrhage. Various routes of misoprostol administration under study include oral, vaginal, buccal, sublingual and rectal. MATERIALS AND METHODS This was an open-label, randomized, cross-over study of the pharmacokinetic differences of buccal vs. sublingual m...

Misoprostol (PGE1) is a drug that very commonly used in obstetrics for labour induction. Apart from its side effect of causing congenital malformations offspring users who have unsuccessfully it as an abortifacient, considered safe with few effects. We here report severe hypersensitivity reaction to misoprostol 33-year-old term pregnant patient non-allergic vaginal misoprostol. The developed an...

OBJECTIVE To compare the impact of 1000 micrograms of self-administered vaginal misoprostol versus self-administered vaginal placebo on preoperative cervical ripening after pre-treatment with estradiol vaginal tablets at home in postmenopausal women prior to day-care operative hysteroscopy. DESIGN Randomised double-blind placebo-controlled sequential trial. The boundaries for the sequential t...

The aim of this prospective study was to assess the efficacy of intra-cervical misoprostol in the management of early pregnancy failure. Twenty women with early pregnancy failure received intra-cervical misoprostol via an endometrial sampling cannula. The first dose was 50 μg of misoprostol dissolved in 5 ml of normal saline. The administration was repeated after 12 h if there was no vaginal bl...

BACKGROUND The pharmacokinetics of a novel slow-release (SR) misoprostol was studied and compared to conventional misoprostol. METHODS Thirty-one women, pregnant between 8 and 12 weeks, requesting surgical abortion were randomly allocated to receive orally 400 microg conventional misoprostol, 400 microg SR misoprostol or 800 microg SR misoprostol. Venous blood samples were taken at 0, 30, 60,...