Cytochrome P450 (P450) enzymes primarily catalyze mixed-function oxidation reactions, plus some reductions and rearrangements of oxygenated species, e.g. prostaglandins. Most of these reactions can be rationalized in a paradigm involving Compound I, a high-valent iron-oxygen complex (FeO), to explain seemingly unusual reactions including ring couplings, ring expansion and contraction, and fusio...

The corrosion of zero-valent iron (Fe0(s)) by oxygen (O2) can lead to the oxidation of organic compounds. To gain insight into the reaction mechanism and to assess the nature of the oxidant, the oxidation of methanol, ethanol, 2-propanol, and benzoic acid by the reaction of nanoparticulate zero-valent iron (nZVI) or ferrous iron (Fe[II]) with O2 in the absence of ligands was studied. At pH valu...

Recent advances in nanoscience and nanotechnology have also led to the development of novel nanomaterials, which ultimately increase potential health and environmental hazards. Interest in developing environmentally benign procedures for the synthesis of metallic nanoparticles has been increased. The purpose is to minimize the negative impacts of synthetic procedures, their accompanying chemica...

Voltaire (1694-1778), the French philosopher said: “There are many ways to waste own time: Doing nothing, doing the wrong thing, doing the good thing at the wrong time” (own translation). The situation is quite different if the time is robbed by someone else or even by a professional mistake. There is a clear evidence that researchers on metallic iron (Fe0 termed as zero-valent iron) for water ...

Abstract Zero-valent iron has been used for more than 130 years water treatment. It is based on redox reactions as well sorption to the corrosion products of iron. successfully applied removal metals and organic pollutants from groundwater wastewater. There are different variations how zero-valent can be used, especially (i) permeable reactive barriers, (ii) fluidized bed reactors (iii) nanosca...

Metalloproteins that catalyse the incorporation of oxygen atom derived from dioxygen into organc substrates usually contain either iron or copper. Our understanding of the mechanism involved in the reaction of the iron-containing heme oxygenases has been substantially advanced by the characterization of high-valent iron porphyrin oxo-complexes capable of epoxidation or hydroxylation of organic ...

High-valent iron oxidants are known to be the catalytically active species in heme enzymes, and the last decade has seen similar developments in non-heme-iron biomimetics and biochemistry. 2] Extensive reactivity studies, structural, spectroscopic, and computational work have established {FeOOH} and {Fe=O} as relevant intermediates in catalytic oxygenation processes. The species {Fe=O} has also...

The systematic oxidation reactions of a wide range of alcohols have been carried out by using an iron porphyrin complex in order to understand their relation to cytochrome P-450 enzymes and to have a practical application to organic synthesis. The iron porphyrin complex catalyzed efficiently alcohol oxidation to the respective carbonyl compound via a high-valent iron-oxo porphyrin intermediate ...