Latent Growth Curve Models (LGCM) are discussed as a general data-analytic approach to the analysis of change. Conventional, but popular, methods of analyzing change over time, such as the paired t-test, repeated measures ANOVA, or MANOVA, have a tradition, which is quite different from the more recently developed latent growth curve models. While the former originated from the idea of variance...

Analysis of variance (Anova) is an extremely important method in exploratory and confirmatory data analysis. Unfortunately, in complex problems (for example, splitplot designs), it is not always easy to set up an appropriate Anova. We propose a hierarchical analysis that automatically gives the correct Anova comparisons even in complex scenarios. The inferences for all means and variances are p...

Analysis of variance (ANOVA) is an extremely important method in exploratory and confirmatory data analysis. Unfortunately, in complex problems (e.g., split-plot designs), it is not always easy to set up an appropriate ANOVA. We propose a hierarchical analysis that automatically gives the correct ANOVA comparisons even in complex scenarios. The inferences for all means and variances are perform...

We evaluate by simulation three model-based methods to test the influence of a single nucleotide polymorphism on a pharmacokinetic parameter of a drug: analysis of variance (ANOVA) on the empirical Bayes estimates of the individual parameters, likelihood ratio test between models with and without genetic covariate, and Wald tests on the parameters of the model with covariate. Analyses are perfo...

Cleft lip and palate (CLP) affects the dentoalveolar and nasolabial facial regions. Internal and external nasal dysmorphology may persist in individuals born with CLP despite surgical interventions. 7-18 year old individuals born with unilateral and bilateral CLP (n = 50) were retrospectively assessed using cone beam computed tomography. Anterior, middle, and posterior nasal airway volumes were...