Increased lung vascular permeability is an important contributor to respiratory failure in acute lung injury (ALI). We found that a function-blocking antibody against the integrin v 5 prevented development of lung vascular permeability in two different models of ALI: ischemia-reperfusion in rats (mediated by vascular endothelial growth factor [VEGF]) and ventilation-induced lung injury (VILI) i...

The role of platelets in responding to vascular injury and the prevention blood loss is very well understood. Cloutier and colleagues have now used fluorescent microspheres, 2-photon microscopy, and genetically modified mice to convincingly demonstrate that in addition to their role in hemostasis, platelets can also promote vascular leakage. More importantly, using a model of rheumatoid arthrit...

1. The administration of crude renal extract to bilaterally nephrectomized rats causes an increase in vascular permeability to plasma proteins. This is associated with a fall in plasma volume. The active material resembles the enzyme renin in pressor activity, heat-lability, pH range of activity and molecular size. 2. To test the possibility that renin might be responsible, renin was extracted ...

The role of vascular permeability in the preferential accumulation of photosensitizers in tumor tissue was investigated. Two murine tumors [experimental mammary tumor carcinoma (EMT-6) and methylcholanthrene-induced rhabdomyosarcoma (M1S)] and a human bladder carcinoma (EJ) were grown s.c. on the flank in athymic nude mice and analyzed for in vivo vessel permeability, vascular permeability fact...

Connexin (Cx)43 has been shown to participate in several cardiovascular diseases. Increased vascular permeability is a common and severe complication in sepsis or septic shock. Whether or not Cx43 takes part in the regulation of vascular permeability in severe sepsis is not known, and the underlying mechanism has not been described. With cecal ligation and puncture-induced sepsis in rats and li...

The role of vascular permeability in the preferential accumulation of photosensitize» in tumor tissue was investigated. Two murine tumors [experimental mammary tumor carcinoma (EMT-6) and methylcholanthrene-induced rhabdomyosarcoma (MIS)] and a human bladder carci noma (EJ) were grown s.c. on the flank in athymic nude mice and analyzed for in vivo vessel permeability, vascular permeability fac...

Dysregulation of the blood-brain barrier (BBB) is a hallmark feature of numerous neurologic disorders as diverse as multiple sclerosis, stroke, epilepsy, viral hemorrhagic fevers, cerebral malaria, and acute hemorrhagic leukoencephalitis. CD8 T cells are one immune cell type that have been implicated in promoting vascular permeability in these conditions. Our laboratory has created a murine mod...

Background Hypercholesterolemia promotes endothelial dysfunction and neovascularization, which increase net vascular permeability and promote atherosclerosis. We have previously reported that gadofosveset, a clinically approved albumin-binding MR contrast agent, can be used to assess endothelial permeability, plaque progression/ regression in a murine model of atherosclerosis. Here, we used gad...

BACKGROUND AND AIMS The extent and molecular mechanisms governing plasma extravasation and formation of ascites in cirrhosis are unknown. Vascular endothelial growth factor-A (VEGF-A) and angiopoietin-2 (Ang-2) are endogenous substances with powerful vascular permeability effects. We assessed regional blood flow, vascular leakage, mRNA and tissular expression of VEGF-A and Ang-2 and vascular pe...