We developed a naringenin–hesperidin molar mixture (MIX–160) with proven antihyperglycemic and vasorelaxant activity in preclinical studies. A solid dosage form was manufactured to improve the bioavailability properties. In current study, we sought evaluate oral toxicity of MIX–160 form, which showed no mortality or significant changes body weight, food consumption tissue/organ mass rats. Three...

Plants are the key source for production of novel therapeutic products new medicines. The biological properties plant species used world wide mainly accountable their secondary metabolites obtained from plants. goal this analysis is to summarize chemical composition and effects genus Sida (Malvaceae) identify potential research opportunities. This draws on literature review scientific journals,...

The purpose of this study was to elucidate the interactions between pituitary adenylate cyclase-activating peptide (PACAP)-(1--38) and phospholipids in vitro and to determine whether these phenomena modulate, in part, the vasorelaxant effects of the peptide in the intact peripheral microcirculation. We found that the critical micellar concentration of PACAP-(1--38) was 0.4-0.9 microM. PACAP-(1-...