The increase in adiponectin levels in obese patients with untreated dyslipidemia and its mRNA expression in adipose tissue of obese animals are one of the most interesting consequences of rimonabant treatment. Thus, part of rimonabant's metabolic effects could be related to an enhancement of adiponectin secretion and its consequence on the modulation of insulin action, as well as energy homeost...

Using rapid centrifugal filtration (<or= 30 min) of diluted samples, the filter membrane prevented compounds with molecular weight higher than the nominal molecular weight limit (NMWL) from transporting through the membrane, thus separating them from compounds with molecular weight smaller than NMWL, which would pass through the membrane. The purpose of this study aims to remove high molecular ...

BACKGROUND/OBJECTIVES We examined the hypoglycemic and anti-hyperlipidemic effect of yeast hydrolysate (YH) enriched with Cyclo-His-Pro (CHP) in the C57BL/6J ob/ob mouse model. MATERIALS/METHODS Mice were separated into 4 groups (8 mice/group) on the basis of blood glucose and body weight: WT control, lean mice given vehicle; ob/ob control, ob/ob mice given vehicle; YH-1, ob/ob mice given 0.5...

Oncostatin M (OSM) has been reported to stimulate angiogenesis by upregulating VEGF and bFGF, implying that it could be a therapeutic strategy in treating ischemic diseases. The present study was aimed at investigating whether OSM could improve cardiac function via prompting angiogenesis following myocardial infarction (MI). Wild type (WT) and Oβ knock-out (Oβ (-/-)) mice were, respectively, ra...

This paper presents the application of neuro-fuzzy method for prediction of vehicle fuel consumption prediction. Prediction motor vehicle fuel consumption has become a strategic issue, because it is not only related to the issue of availability of fuel but also the problem of the environmental impact caused. This study used automobile data, i.e. number of cylinders, displacement, horsepower, we...

1. Abstract A major challenge in automotive design is the creation of safe vehicles with minimal environmental impact. This study presents a modeling framework for evaluating and optimizing body designs for improved occupant safety and fuel efficiency. Vehicle body mass is considered as the main link between safety and sustainability. The modeling framework includes frontal crash energy absorpt...

many studies have been done on hybrid vehicles in the past few years. the full hybrid vehicles need a large number of batteries creating up to 300 (v) to meet the required voltage of electric motor. the size and weight of the batteries cause some problems. this research investigates the mild hybrid vehicle. this vehicle includes a small electric motor and a high power internal combustion engine...

The aim of the present study was to analyze the effect of polycan, a β-glucan originating from Aureobasidium, on high-fat diet (HFD)-induced hyperlipemia and hepatic damage. A total of 30 hamsters were divided into 6 groups based on their body weight following acclimatization: control, sham, simvastatin (SIMVA) and 3 Polycan groups. In the polycan groups, Polycan, at three concentrations (31.25...

INTRODUCTION This study was undertaken to investigate the effects of pumpkin seed oil alone or combined with Phytosterol-F on testosterone/prazosin-induced (T-P) prostate growth in rats. MATERIALS AND METHODS Forty adult Wistar rats were divided into five groups, including: one control group, rats treated with vehicle only, one group treated with T-P, and two groups of T-P-treated rats, one r...

The most studied combinatorial optimization problem in transport and logistics is the vehicle routing problem (VRP). The goal of the vehicle routing problem is to nd a set of routes for a eet of vehicles which optimises the objective function (e.g. total distance, routing costs). Every demand needs to be ful lled and vehicle capacities need to be respected. Many solution methods exist for the '...