Acquired nystagmus occurs frequently in patients with multiple sclerosis and is often the cause of illusory motion of the environment (oscillopsia), and blurring of vision. Based primarily on the beneficial effect of gabapentin on acquired pendular nystagmus (APN), a GABAergic mechanism in controlling nystagmus has been hypothesised. If increasing GABA concentrations in the CNS are critical for...

Vigabatrin and baclofen given together, at doses not affecting motor performance, produced dose-dependent inhibition of both phases in the formalin test in mice. Isobolographic analysis revealed a significant synergy between both drugs in both phases of the forrmalin test.

Ten patients who developed a major depressive episode in association with vigabatrin treatment for intractable epilepsy are reported. The depression usually occurred early in the course of treatment, but when delayed followed a recent increase in dose. Depressive symptoms occurred at doses varying between 1.5 g and 4 g a day, often but not always when patients were experiencing a decrease in th...

The title compound, [Ni(C(5)H(5))(C(13)H(7)N(2))(C(18)H(15)P)] or (η(5)-C(5)H(5))(PPh(3))Ni-C C-C(7)H(6)-C(H)=C(CN)(2), contains an unusual disubstituted norbornadienyl (NBD) ligand containing ethynyl (-C C-) and dicyano-vinyl [-C(H)=C(CN)(2)] groups. Disorder is present in the NBD group with site occupancies of 0.636 (10) and 0.364 (10) for two distinct orientations. There are no strong hydrog...

OPINION STATEMENT The treatment of epilepsy is complicated by the multiple seizure types and epilepsy syndromes needing therapy. In addition, seizures in up to 30% of epilepsy patients are resistant to available medications. The three newest antiepileptic medications (lacosamide, rufinamide, and vigabatrin) all putatively have novel mechanisms of action, which might increase the chance of treat...

Background: Hepatotoxicity is one of the most important side effects anticonvulsant drugs. This study compared hepatotoxicity sodium valproate, carbamazepine, phenytoin, lamotrigine, and vigabatrin in male rats. Methods: Based on results, 56 rats were randomly divided into seven groups eight treated intraperitoneally for four weeks. Groups 1 2 received 500 mg/kg carbamazepine 3, 4, 5 injected w...