The auristatin class of microtubule destabilizers are highly potent cytotoxic agents against several cancer cell types when delivered as antibody drug conjugates. Here we describe the high resolution structures of tubulin in complex with both monomethyl auristatin E and F and unambiguously define the trans-configuration of both ligands at the Val-Dil amide bond in their tubulin bound state. Mor...

Vincristine (VCR) is a vinca alkaloid that is used for treatment of many malignancies. The vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects. Described here is the case of a 2.5-year-old boy, a known case of Wilms' tumor, treated by vincristine (0.067 mg/kg/day) and dactinomycin (0.045 mg/kg/day) after surgery. Three weeks...

The strive of this assessment shows that Vinca rosea, many obviously grown vegetation round us which can be used for medicinal purposes. It has known names like vinca Rosea, Madagascar periwinkle, vibrant eyes, Cape graveyard plant, old maid, crimson rose periwinkle myrtle. Ayurveda is the Indian conventional device medication focuses on scientific capability plant life. Catharanthus roseus one...

Klinik Vinca Rosea merupakan Fisioterapi pertama yang berada di kota Lhokseumawe. Rata-rata setiap tahun nya klinik mengalami peningkatan pasien. vinca rosea telah mengelola 120 item obat terdaftar pada database nya. Perencanaan belum menggunakan analisis dan peramalan kebutuhan sehingga sulit untuk memperkirakan jumlah pemesanan akan datang Hal ini dapat mengakibatkan stock-out menyebabkan kur...

Axonal ultrastructural changes induced by three Vinca alkaloids, vincristine, vinblastine, and desacetyl vinblastine amide, were studied in vitro at concentrations of 0.01, 0.05, and 0.1 mM in the cat vagus nerve. Disruption of microtubules, appearance of paracrystalline structures, and increase in neurofilaments were induced by all three agents at 0.1 mM. A new type of paracrystal with an elec...

This paper reports on the vinca alkaloid produced by a novel Nigrospora sphaerica isolated from Catharanthus roseus. Through liquid chromatography-mass spectrometry (LCMS), only the crude mycelia extract of this fungus was positive for determination of vinblastine. This vinca alkaloid was then purified by using high-performance liquid chromatography (HPLC) and tested for cytotoxicity activity u...

Raising end-user’s programmability is a promising way to ensure more flexible and higher-quality information provision and utilization, and to better cope with spontaneous business requirements as well. This paper presents the state-of-the-art developments of the end-user service composition language VINCA and its corresponding approach to developing end-user programmable applications on the ba...