This is the first study to investigate the biological activities of fermented extracts of Rhodiola rosea L. (Crassulaceae) and Lonicera japonica Thunb. (Caprifoliaceae). Alcaligenes piechaudii CC-ESB2 fermented and ethanol extracts of Rhodiola rosea and Lonicera japonica were prepared and the antioxidative activities of different concentrations of samples were evaluated using in vitro antioxida...

BACKGROUND Rhodiola rosea (R. rosea), a botanical of both western and traditional Chinese medicine, has been used as a folk remedy for improving stamina and reducing stress. However, few controlled clinical trials have examined the safety and efficacy of R. rosea for the treatment of major depressive disorder (MDD). This study seeks to evaluate the safety and efficacy of R. rosea in a 12-week, ...

Developing new methods for chemotherapy drug delivery has become a topic of great concern. Vinca alkaloids are among the most widely used chemotherapy reagents for tumor therapy; however, their side effects are particularly problematic for many medical doctors. To reduce the toxicity and enhance the therapeutic efficiency of vinca alkaloids, many researchers have developed strategies such as us...

Studying the pharmacological activities of vincristine sulfate (VCR), one of the alkaloids isolated from Vinca rosea Linn. by Svoboda et al. (1), Anderson et al. (2) observed the pressor, positive chronotropic and re spiratory stimulating effects in dogs. Since no action mechanisms of these pharmacological effects were reported, the authors attempted to clarify its pressor mechanisms. Pressor e...

Rhodiola rosea is a remarkable herbthat has been a part of traditional medicine systems in order to stimulatethe nervous system, toprotect thebody against oxidative stress, free radical damage, inflammation, and virus infection. Rhodiola rosea is included among a class ofplant derivatives called adaptogen,an agent thathelps the body adapt to various stressors. Adaptogens have been claimed to tr...

Tomato gray mold disease, caused by Botrytis cinerea, is a serious disease in tomato. Clonostachys rosea is an antagonistic microorganism to B. cinerea. To investigate the induced resistance mechanism of C. rosea, we examined the effects of these microorganisms on tomato leaves, along with changes in the activities of three defense enzymes (PAL, PPO, GST), second messengers (NO, H2O2, O2(-)) an...

AIM The present study investigates the effect of combined treatment with Ginkgo biloba and/or Rhodiola rosea on psychomotor vigilance task (PVT) and short-term working memory accuracy. SUBJECTS AND METHODS A total number of 112 volunteers were enrolled to study the effect of G. biloba and R. rosea on PVT and short-term working memory accuracy as compared to placebo effects, the central cognit...

Cancer is deadliest disease ever known. Vinca extract has the potential and beneficial in treating various cancer conditions. However, till date no known syrup of plant or its been formulated. a debilitated condition formulation evaluation herbal alcoholic vinca may serve patient compliance ease administration by oral route. The was formulated using Vinca. Syrups are easy to formulate help over...

A comparative study of the loading and retention properties of three structurally very closely related vinca alkaloids (vincristine, vinorelbine and vinblastine) in liposomal formulations has been performed. All three vinca alkaloids showed high levels of encapsulation when accumulated into egg sphingomyelin/cholesterol vesicles in response to a transmembrane pH gradient generated by the use of...

Background The root extract of Rhodiola rosea has historically been used in Europe and Asia as an adaptogen, and similar to ginseng and Shisandra, shown to display numerous health benefits in humans, such as decreasing fatigue and anxiety while improving mood, memory, and stamina. A similar extract in the Rhodiola family, Rhodiola crenulata, has previously been shown to confer positive effects ...