tional ovarian tumors in laboratory rodents, both by irradiation and by intrasplenic transplants, has been extensively studied, there are fewrecords of spontaneous functional tumors in these animals. Spontaneous ovarian tumors of any variety are uncommon in rats. Bullock and co-workers (2, 4) found only six ovarian tumors in 14,038 female rats observed. We have been unable to find any report in...

Introduction: Ovarian tumor considered one of the most common tumors affected females, it represent 6th overall (4%), and 2nd usual in females international (23%). Worldwide each year, ≥225,000 women were diagnosed, 140,000 die from disease. The aim study is to determine various histopathological morphological variants ovarian tumors, their size site, age distribution, association with diagnosi...

Various ovarian cell types including granulosa cells and ovarian surface epithelial cells express the progesterone (P4) binding protein, progesterone receptor membrane component-1 (PGRMC1). PGRMC1 is also expressed in ovarian tumors. PGRMC1 plays an essential role in promoting the survival of both normal and cancerous ovarian cell in vitro. Given the clinical significance of factors that regula...

The National Toxicology Program (NTP) classification system for rat and mouse ovarian tumors is presented. The classification system is based on previous classification systems and on a review of all the primary ovarian tumors from the archives of the National Cancer Institute (NCI) and NTP Carcinogenesis Testing Programs. The relative frequency and principal diagnostic features of 204 ovarian ...

BACKGROUND Epithelial ovarian carcinoma is a significant cause of cancer mortality in women worldwide and in the United States. Epithelial ovarian cancer comprises several histological subtypes, each with distinct clinical and molecular characteristics. The natural history of this heterogeneous disease, including the cell types of origin, is poorly understood. This study applied recently develo...

OBJECTIVE Currently, there is not a fully characterized model for human ovarian cancer; however, 2- to 4-year-old laying hens spontaneously develop ovarian tumors. CA125 expression is a hallmark of ovarian cancer in women. The major objective of this study was to characterize the in vitro growth of avian ovarian tumor cells, and CA125 expression in avian ovarian tumors. METHODS Immunohistoche...

Few studies have evaluated Hedgehog (Hh) signaling pathway activation in different types of ovarian tumors including benign, borderline and malignant ovarian tumors. The present study investigated the expression of Hh signaling pathway components (SHH, SMO, PTCH, and GLI1) in 193 ovarian epithelial tumor specimens (including 147 malignant epithelial ovarian cancers, 30 borderline ovarian tumors...

Background: Ovarian neoplasm is a type of cancer caused by uncontrolled growth and division cells within the ovary. It common gynecological that affects wide range ages can have various clinical, morphological, histological features. This study aimed to examine relationship between clinical presentation pattern ovarian neoplasm. Methods: cross-sectional conducted among 45 patients admitted depa...

Though the familial occurrence of virilization associated with hyperplasia of the adrenal cortex has long been established, there have been only two reports of the familial aggregation of virilizing adrenal carcinoma. It is the purpose of the present communication to describe a family in which 2 sibs, who were products of a consanguineous marriage, had virilizing tumours ofthe adrenal cortex pr...

One of the main health issues facing general practitioners in and gynecologists particular is ovarian tumors. Ovarian cancer second most prevalent malignancy female reproductive system fifth leading cause cancer-related death women. The majority instances are discovered when disease has already progressed even though early neoplasms benign which emphasizes importance detection.  &nbsp...