OBJECTIVE To determine whether the extent, distribution, and duration of vitiligo are associated with impairment of specific aspects of quality of life. DESIGN A prospective questionnaire-based study of 1541 adults with vitiligo. SETTING Online questionnaire. MAIN OUTCOME MEASURES Affected body surface area (BSA), distribution and duration of vitiligo, associated symptoms, and quality of ...

tyrosinase has been recognized as a major autoantign in human vitiligo. here we have shown that experimental autoimmune vitiligo can be induced by intradermal injection of mushroom tyrosinase emulsified in complete freund’s adjuvant in c57bl/6 mice. the onse of vitiligo was characterized by hair hypopigmentation and total melanocyte depletion in the basal layer of the epidermis. our results con...

The impact of vitiligo on quality of life is controversial. The aim of this study was to observe the impairment of quality of life and emotional state in adults with vitiligo compared with subjects with psoriasis and unaffected controls. The study group comprised 54 subjects with vitiligo, 57 with psoriasis and 57 unaffected controls. All subjects were examined and interviewed using the Dermato...

I read with interest and appreciated the paper of Kiniwa et al. (1), which was published in a recent issue of Cancer Research. They identified a novel melanoma/melanocyte antigen (KU-MEL-1), isolated from a patient with vitiligo and T-cell-infiltrated metastatic melanoma, that induced IgG responses in patients with various cancers and Vogt-Koyanagi-Harada disease but did not in 12 vitiligo pati...

OBJECTIVES Vitiligo is a relatively common autoimmune condition causing loss of skin pigment. Around 1 in 100 people in the UK develop vitiligo. It can have a significant impact on quality of life for many of those affected. How people access information and help for vitiligo may influence how they manage such impact. We aimed to explore people's views and experiences of seeking health informat...

PURPOSE Vitiligo is an acquired pigmentary skin disease that can cause serious cosmetic problems. There have been numerous and well established studies that have demonstrated the comorbidity of various psychiatric disorders in patients with vitiligo. However, to our knowledge, there have been no studies investigating whether a psychiatric biomarker, such as brain-derived neurotrophic factor (BD...

BACKGROUND Vitiligo affects melanocytes in the skin. Since melanocytes are present in other organs as well, it is plausible that they may be similarly affected. METHODS A comparative study of audiological functions was carried out in 180 patients of vitiligo and 60 non-vitiligo controls in the age group of 5-40 years. RESULTS In vitiligo patients sensorineural hypoacusis of mild degree was ...

Objective To determine the familial frequency of vitiligo and its association with autoimmune disorders. Methods This cross-sectional study was conducted in the Department of Dermatology, Mayo Hospital, Lahore. Hundred patients of vitiligo of any age and either sex, diagnosed on the basis of history and clinical examination were enrolled from the outpatient department. Patients were evaluated f...

Vitiligo is an acquired depigmentary disorder of the skin, characterized by multiple susceptibility loci and genetic heterogeneity. The etiology of vitiligo is unknown but several hypotheses, including an autoimmune origin, have been proposed. Tumor necrosis factor (TNF)-α, a pleiotropic proinflammatory cytokine, has been shown to play a critical role in several autoimmune diseases including vi...

BACKGROUND Vitiligo is a common pigmentary disorder of the skin, affecting individuals globally. Not only is this ailment psychologically incapacitating, it also has a high incidence of autoimmunity, signifying that its manifestations may be the portrayal of dysfunction of immune system. OBJECTIVE The aim of this study is to find out the situations of abnormal thyroid function test (TFT) in v...