A series of pleuromutilin derivatives were synthesized by two synthetic procedures under mild reaction conditions and characterized by Nuclear Magnetic Resonance (NMR), Infrared Spectroscopy (IR), and High Resolution Mass Spectrometer (HRMS). Most of the derivatives with heterocyclic groups at the C-14 side of pleuromutilin exhibited excellent in vitro antibacterial activities against Staphyloc...

objectives: the objective of this study was to analyze the fatty acid content, antioxidant, and antibacterial activities of hydro-methanolic extract of adonis wolgensis l. (a. wolgensis l.) growing wild in north of iran. materials and methods: oils of a. wolgensis l. was obtained by means of soxhlet apparatus from leaves and stems. methyl esters were derived from the oily mixtures by trans-este...

substituted 1, 2, 4- triazoles have shown multiple biological activities such as anti-inflammatory, anti fungal, etc. 5-mercapto triazoles were prepared from the potassium dithiocarbazinates. these triazoles were used for preparation of different derivatives by two different schemes. in the first scheme the mannich bases were prepared from 5- marcapto-s triazole quinazolines. the 5-marcato-s-tr...

Background & Aim: Secondary metabolites with bioactive and functional properties in essence of aromatic plants can be useful for improvement of quality and persistence of food as natural preservative.  The aim of this study was to evaluate the in vitro antibacterial of essential oils of some of the medicinal plants collected from Chaharmahal va Bakhtiari Province, Iran. Experimental: ...

antibacterial activity of the aerial extracts from xanthium brasilicum prepared in methanol, diethyl ether, petroleum benzene and an equal mixture of the three solvents were studied against bacterial laboratory standards and clinical isolates using the disk diffusion method. the best antibacterial results were obtained when methanol or the solvent mixture was used. the crude extract with the hi...

Cephalosporins are chemotherapeutic agents whose spectrum and use are limited to antibacterial activity. Therefore, it was of interest to find several new semisynthetic cephalosporins which possess in vitro antifungal activity against Trichophyton mentagrophytes, Candida albicans and certain other yeasts. Five new cephalosporins containing the 2-pyridinethiol 1-oxide grouping were examined. Fou...

In this study, we report the antibacterial activities of six polyphenols (i.e., luteolin, quercetin, scutellarin, apigenin, chlorogenic acid, and resveratrol) against 29 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), and in vitro antibacterial activities of two-drug combinations. All of the MRSA strains evaluated were clinical isolates from patients with MRSA bacteremi...

Background & Aim: During human history, most of infectious diseases have been cured with herbal drugs traditionally so that, nowadays, in most developing countries, herbal drugs play an important role in primal remedy. This study has been done according to the appropriate climate and biodiversity of plants in Golestan province in order to investigate the antimicrobial activity of alcoholics, aq...

5-Thiourea and 5-dithiocarbamate oxazolidinones were synthesized as a continuation of research on 5-thiocarbonyl oxazolidinone antibacterial agents considering the hydrophobic parameters of the molecule. The structure-activity relationship (SAR) study revealed that the antibacterial activity on 5-thiocarbonyl oxazolidinones was significantly affected by the lipophilicity, especially the calcula...